- Method for preparing benzamide compound
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The invention provides a method for preparing a benzamide compound, and belongs to the technical field of organic synthesis. The method for preparing a benzamide compound provided by the invention comprises the following steps: mixing aryl-substituted dihydrooxazole, an acidic catalyst, water and a reaction solvent, and carrying out hydrolysis ring-opening reaction to obtain the benzamide compound, wherein the acidic catalyst is p-toluenesulfonic acid or sulfonic acid ion exchange resin. According to the invention, p-toluenesulfonic acid or sulfonic acid ion exchange resin is used as an acidiccatalyst, under the catalytic action of the p-toluenesulfonic acid or sulfonic acid ion exchange resin, aryl-substituted dihydrooxazole is subjected to hydrolysis ring-opening reaction to obtain thebenzamide compound, only metered toluenesulfonic acid or sulfonic acid ion exchange resin needs to be catalyzed, the toluenesulfonic acid or sulfonic acid ion exchange resin is convenient to remove after the reaction is completed, almost no waste is generated, and industrial production is convenient to achieve.
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Paragraph 0053-0062
(2020/06/30)
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- Process for the manufacture of acetonylbenzamides
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Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.
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- Method for controlling resistant fungi
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A method for controlling phytopathogenic fungi is disclosed. The method uses a fungicidal composition which has been found to be effective against strains of fungi which are resistant to benzimidazole fungicides. When combined with one or more of benzimidazole, thiophanate, or dicarboximide fungicides, and applied to a mixed population of sensitive and resistant fungi, the fungicidal compound of the present invention is more effective against the mixed population of fungi than either of the fungicidal compounds alone.
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- Metal salt catalyzed process to oxazolines and subsequent formation of chloroketones
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This invention relates to a process for the preparation of an α-chloroketone compound comprising the steps of (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene, R is a hydrogen atom or alkyl, and R1and R2are each independently an alkyl or substituted alkyl group, or R1and R2together with the carbon atom to which they are attached form a cyclic structure. Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.
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- Development of a process for triazine-promoted amidation of carboxylic acids
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A process has been developed for the triazine-promoted amidation of carboxylic acids. We have identified 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) as a cost-effective reagent for this transformation. The procedure is a suitable alternative to traditional amidation processes when an acid chloride cannot be prepared from the corresponding carboxylic acid due to safety, stability, or handling concerns.
- Rayle, Heather L.,Fellmeth, Lisa
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p. 172 - 176
(2013/09/08)
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- Process for the manufacture of acetonylbenzamides
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Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.
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- Method for controlling resistant fungi
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A method for controlling phytopathogenic fungi is disclosed. The method uses a fungicidal composition which has been found to be effective against strains of fungi which are resistant to benzimidazole fungicides. When combined with one or more of benzimidazole, thiophanate, or dicarboximide fungicides, and applied to a mixed population of sensitive and resistant fungi, the fungicidal compound of the present invention is more effective against the mixed population of fungi than either of the fungicidal compounds alone.
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