- SUBSTITUTED HETEROCYCLIC COMPOUNDS
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Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
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- Stereoselective Radical-Mediated Cyclization of Norephedrine Derived α-Iodoamides: Synthesis of Enantiopure Pyrrolidines and Transition State Modelling
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Radical-mediated cyclization of norephedrine derived α-iodoamides 1 was found to be highly stereoselective ( 97:3) favouring diastereoisomer 2.Bicyclic lactams 2 were transformed in high yields into enantiomerically pure pyrrolidines 10.Transition stat
- Belvisi, Laura,Gennari, Cesare,Poli, Giovanni,Scolastico, Carlo,Salom, Barbara,Vassallo, Marco
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p. 3945 - 3960
(2007/10/02)
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- Stereoselective Radical-Mediated Cyclization of Norephedrine Derived α-Iodoamides: Experiments and TS-Modelling
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Radical-mediated cyclization of norephedrine derived α-iodoamides 1 was found to be highly stereoselective (97:3) favouring diastereoisomer 2.Transition state modelling with a force field developed ad hoc, nicely predicts the stereochemical results.
- Gennari, Cesare,Poli, Giovanni,Scolastico, Carlo,Vassallo, Marco
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p. 793 - 796
(2007/10/02)
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