16251-50-6

Basic information

• Product Name: (1S,2R)-(+)-2-chloro-N-(2-hydroxy-1-methyl-2-phenylethyl)acetamide
• Synonyms: (1S,2R)-(+)-2-chloro-N-(2-hydroxy-1-methyl-2-phenylethyl)acetamide
• CAS NO: 16251-50-6
• Molecular Weight: 227.691
• Mol File: 16251-50-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1S,2R)-(+)-2-chloro-N-(2-hydroxy-1-methyl-2-phenylethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-(+)-2-chloro-N-(2-hydroxy-1-methyl-2-phenylethyl)acetamide(16251-50-6)
• EPA Substance Registry System: (1S,2R)-(+)-2-chloro-N-(2-hydroxy-1-methyl-2-phenylethyl)acetamide(16251-50-6)

Safety Data

• Hazardous Substances Data: 16251-50-6(Hazardous Substances Data)

Upstream product

• 492-41-1 (1R,2S)-norephedrine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 137314-81-9 2-Chloro-1-((2S,4S,5R)-4-methyl-5-phenyl-2-vinyl-oxazolidin-3-yl)-ethanone 
• 142955-01-9 2-Chloro-1-((2R,4S,5R)-4-methyl-5-phenyl-2-vinyl-oxazolidin-3-yl)-ethanone 
• 137314-85-3 2-Iodo-1-((2S,4S,5R)-4-methyl-5-phenyl-2-vinyl-oxazolidin-3-yl)-ethanone 
• 142954-96-9 2-Iodo-1-((2R,4S,5R)-4-methyl-5-phenyl-2-vinyl-oxazolidin-3-yl)-ethanone 
• 137314-86-4 2-Iodo-1-[(2S,4S,5R)-4-methyl-5-phenyl-2-((E)-propenyl)-oxazolidin-3-yl]-ethanone 
• 137314-86-4 2-Iodo-1-[(2R,4S,5R)-4-methyl-5-phenyl-2-((E)-propenyl)-oxazolidin-3-yl]-ethanone 
• 143060-10-0 (E)-3-[(2S,4S,5R)-3-(2-Chloro-acetyl)-4-methyl-5-phenyl-oxazolidin-2-yl]-acrylic acid methyl ester 
• 143060-11-1 (E)-3-[(2R,4S,5R)-3-(2-Chloro-acetyl)-4-methyl-5-phenyl-oxazolidin-2-yl]-acrylic acid methyl ester 
• 143060-05-3 (E)-3-[(2S,4S,5R)-3-(2-Iodo-acetyl)-4-methyl-5-phenyl-oxazolidin-2-yl]-acrylic acid methyl ester 
• 143060-03-1 (E)-3-[(2R,4S,5R)-3-(2-Iodo-acetyl)-4-methyl-5-phenyl-oxazolidin-2-yl]-acrylic acid methyl ester 
• 137314-90-0 (2R,3S,7R,7aS)-3,7-Dimethyl-2-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 137314-92-2 ((2R,3S,7S,7aS)-3-Methyl-5-oxo-2-phenyl-hexahydro-pyrrolo[2,1-b]oxazol-7-yl)-acetic acid methyl ester 
• 137431-01-7 (2R,3S,7R,7aS)-7-Ethyl-3-methyl-2-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 142954-98-1 (2R,3S,7R,7aS)-7-Iodomethyl-3-methyl-2-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC COMPOUNDS

Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

Stereoselective Radical-Mediated Cyclization of Norephedrine Derived α-Iodoamides: Experiments and TS-Modelling

Radical-mediated cyclization of norephedrine derived α-iodoamides 1 was found to be highly stereoselective (97:3) favouring diastereoisomer 2.Transition state modelling with a force field developed ad hoc, nicely predicts the stereochemical results.