- Butyric acid clevidipine preparation method
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The invention discloses a preparation method of clevidipine butyrate, comprising the following steps: (1) carrying out one-pot reaction by putting 2,3-dichlorobenzaldehyde, methyl acetoacetate and 3-amino crotonic acid ethyl cyanide in a solvent under the action of a catalyst; (2) carrying out recrystallization to obtain a pure product (+/-)-3-(2-cyanoethyl)-5-methyl-4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid; (3) carrying out a reaction between the pure product and alkali; (4) adding water and hydrochloric acid, and collecting an intermediate from reaction products; and (5) carrying out a reaction between the intermediate and n-chloromethyl butyrate in the presence of an alkaline substance and an iodide catalyst, and finally collecting the target product clevidipine butyrate from reaction products. The preparation method provided by the invention has advantages of high yield, stable product quality and low cost, is simple to operate, and is suitable for industrial product of clevidipine butyrate.
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Paragraph 0040; 0060-0061
(2017/01/17)
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- Butyric acid clevidipine synthetic method
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The invention discloses a synthetic method of cleviprex. The method comprises the following steps: reacting a compound 1 with a compound 2 in the presence of tetrahydrofuran and triethylamine to generate a compound 3, dissolving the compound 3, a compound
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Paragraph 0052-0054
(2016/10/10)
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- PROCESS FOR PREPARATION OF CLEVIDIPINE AND ITS INTERMEDIATE
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The present invention relates to a process for the removal of t-butyl group from t-butyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate to provide-1,4-dihydro-2,6-dimethyl-4-(2',3'-dichorophenyl)-5-methoxycarbonyl-3-pyr
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Page/Page column 6
(2012/06/15)
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- Preparation of dihydropyridines
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The invention relates to a novel method and novel compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these new compounds useful for the preparation of clevidipine (also k
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Page/Page column 17
(2011/12/01)
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- PREPARATION OF DIHYDROPYRIDINES
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The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidip
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Page/Page column 12
(2011/11/13)
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- PREPARATION OF INTERMEDIATES FOR THE SYNTHESIS OF DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS
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4- (2,3- dichlorophenyl) -1,4- dihydro- 2,6- dimethyl- 5- methoxycarbonyl- 3- pyridinecarboxylic acid, a key intermediate in the synthesis of the cardiovascular calcium channel blocker drug 3-butanoyloxymethoxycarbonyl-5- methoxycarbonyl-4- (2,3-dichlorop
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Page/Page column 7
(2011/11/06)
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- PREPARATION OF CLEVIDIPINE BUTYRATE
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The current application relates to a process for preparing O3-(butanoyloxymethyl)-O5-methyl-4-(2, 3-dichlorophenyl)-2,6-dimethyl-1,4- dihydropyridme-3,5-dicarboxylate, clevidipine butyrate, by alkylation of 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-
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Page/Page column 4
(2011/11/01)
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- Manufacturing process
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A method for the manufacture of clevidipine by reaction of an inorganic salt of 4-(2′,3′-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridine-carboxylate and chloro methyl butyrate.
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Page column 4
(2008/06/13)
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- SHORT-ACTING DIHYDROPYRIDINES
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Compounds of the general formula wherein R1 and R2 are independently selected from the group consisting of hydrogen, chloro, bromo, nitro, cyano, trifluoromethyl, and R3 and R4 are independently selected from straight or branched lower (1-5 carbon atoms)
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- Pharmaceutical emulsion
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A pharmaceutical emulsion for intravenous administration is disclosed which comprises a) a short acting dihydropyridine compound; b) a lipid phase; c) an emulsifier and d) water or a buffer.
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