cas 168263-82-9, (2S,4S)-4-BOC-AMINO PYRROLIDINE-2-CARBOXYLIC ACID METHYLESTER-HCL | Articles data ｜lookchem

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168263-82-9

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THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY
To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: -CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].
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Page/Page column 30

(2008/06/13)

Two prolines with a difference: contrasting stereoelectronic effects of 4R/S-aminoproline on triplex stability in collagen peptides [pro(X)-pro(Y)-Gly]n.
4R/S-Aminoprolines when present in the X-position of collagen peptide [pro(X)-pro(Y)-Gly]n exhibit pH- and stereochemistry-dependent effects on triplex stability.
Umashankara,Babu, I Ramesh,Ganesh, Krishna N
p. 2606 - 2607
(2007/10/03)

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Chemical Properties

Boiling Point: 347.0±42.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
Storage Temp.:Keep in dark place,Sealed in dry,Store in freezer, under -20°C
PKA: 11.90±0.40(Predicted)
PSA: 76.66000
LogP: 1.93630

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