cas 170804-18-9, ETHYL 3-AMINO-4,4,4-TRIFLUOROBUTYRATE | Articles data ｜lookchem

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170804-18-9

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BICYCLOHEPTANE PYRROLIDINE OREXIN RECEPTOR AGONISTS
The present invention is directed to bicyclo[4.1.0]heptane pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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Paragraph 0544; 0546

(2022/03/02)

Ethyl-4,4,4-trifluoroacetoacetate (ETFAA), a powerful building block for enantiopure chirons in trifluoromethyl-β-amino acid series
Herein are studied new transformations of ethyl-4,4,4-trifluoroacetoacetate (ETFAA), giving access to a series of enantiopure chirons bearing both a trifluoromethyl group and an amino moiety. The key intermediate is obtained optically pure by a resolution
Michaut, Valérie,Metz, Fran?ois,Paris, Jean-Marc,Plaquevent, Jean-Christophe
p. 889 - 895
(2008/03/14)

A convenient synthesis of perfluoroalkylated enamines and vinyl phosphonates
The reaction of fluoroalkynes with ammonia and benzylamine gave perfluoroalkylated enamines predominantly as the Z isomer, which were hydrogenated with palladium on carbon to afford perfluoroalkylated β-amino acids in good yield.The reaction of fluoroalky
Cen, Wenbiao,Ni, Yuhua,Shen, Yanchang
p. 161 - 164
(2007/10/02)

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Chemical Properties

Melting Point: 100-102 °C
Boiling Point: 186.2 °C at 760 mmHg
Flash Point:66.4 °C
Density: 1.222 g/cm³
Storage Temp.:2-8°C
Vapor Pressure: 0.671mmHg at 25°C
Refractive Index: 1.3831
PKA: 4.72±0.50(Predicted)
Sensitive: Air Sensitive
BRN: 6136102
PSA: 52.32000
LogP: 1.52950

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