A new one-step-method for the synthesis of 2-phenylpyrimidines of type I was developed by reacting benzotrichloride with various nitriles in the presence of aluminum chloride.
PhICl2-mediated conversion of enamines into α, N -dichloroimines and their reverse conversion mediated by zinc in methanol
Treatment of enamine compounds with iodobenzene dichloride (PhICl 2) conveniently gives a variety of α,N-dichloroimines in high yields. This approach allows the double insertion of the chloro moiety, which is postulated to take place via the io
Tang, Linlin,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
supporting information
p. 1621 - 1629
(2014/06/23)
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation
The synthesis and structure-activity relationship studies of isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors are discussed. The pharmacokinetic profile of 10 and 21 with adequate CNS penetration, required for in vivo Parkinson's disease mod