- Method for preparing azinamide
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The invention discloses a method for preparing azinamide. The method comprises preparing an azinamide thiol compound solution, preparing the azinamide by reaction, and then purifying the azinamide. The method is characterized in that in the process of preparing of the azinamide thiol compound solution, water and sodium sulfide are mixed and dissolved; sulfur is added and dissolved; a 3,6-dichloropyridazine reaction system is added in batches, sodium sulfite is added to prevent oxidation; in the process of preparing of the azinamide, first the sodium sulfite is added to prevent oxidation, thena liquid mixture of ethanol and N,N-diethyl-2-chloroacetamide is added dropwise, meanwhile pH is monitored within the range of 8-10; and the azinamide is purified. The method for preparing the azinamide has the advantages of being simple in steps, green, environmentally-friendly, high in yield, low in processing cost, and suitable for mass production.
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Paragraph 0043; 0044; 0049; 0050; 0055; 0056
(2018/07/30)
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