- A BIOMIMETIC SYNTHESIS OF -CORYNOLINE, -11-EPICORYNOLINE, -ISOCORYNOLINE, AND -EPIISOCORYNOLINE FROM CORYSAMINE
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A novel and efficient synthesis of hexahydrobenzophenanthridine alkaloids, -corynoline, -11-epicorynoline, -isocorynoline, and -11-epiisocorynoline was accomplished from protoberberine alkaloid, corysamine through a biogenetic route.
- Hanaoka, Miyoji,Yoshida, Shuji,Mukai, Chisato
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p. 6621 - 6624
(2007/10/02)
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- Photocyclisation of Enamides. Part 17. Total Synthesis of (+/-)-Corynoline, (+/-)-12-Hydroxycorynoline, and (+/-)-11-Epicorynoline
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Photocyclisation of the enamide (1) followed by stereoselective functionalisation of the cis-lactam (4c) completed the first total synthesis of the alkaloids, (+/-)-corynoline (7e), (+/-)-12-hydroxycorynoline (7d), and (+/-)-11-epicorynoline (7c).Participation of the basic nitrogen in the oxidation with peracid was also suggested.
- Ninomiya, Ichiya,Yamamoto, Okiko,Naito, Takeaki
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p. 212 - 216
(2007/10/02)
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