CDI-mediated monoacylation of symmetrical diamines and selective acylation of primary amines of unsymmetrical diamines
A highly efficient and green protocol for monoacylation of symmetrical diamines and chemoselective acylation of primary amines of unsymmetrical diamines has been developed.
Imidazole-catalyzed monoacylation of symmetrical diamines
Figure Presented. An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.
Verma, Sanjeev K.,Acharya,Kaushik
supporting information; experimental part
p. 4232 - 4235
(2010/11/04)
Microwaves-assisted solvent-free synthesis of N-acetamides by amidation or aminolysis
The preparation of acetamides directly from amines and an acetyl donor under microwaves without any catalyst is described. The inexpensive, solvent free, and fast reaction conditions are the important features of this procedure.