cas 19237-84-4, Prazosin hydrochloride | Articles data

Novel cyanocarboxamidines are disclosed. The new cyanocarboxamidines are particularly valuable as intermediates in the preparation of antihypertensive 4-amino-2-(4-substituted-piperazin-1-yl)-quinazolines.

The invention relates to novel and valuable crystalline forms of the hypotensive agent prazosin hydrochloride. The anhydrous α-form is preferred because it is relatively non-hygroscopic and hence possesses important advantages in handling and formulation. The polyhydrate form of prazosin hydrochloride is preferred because of its low, uniform rate of dissolution.

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Chemical Properties

Appearance/Colour :off-white to yellow powder

Melting Point: 277 - 280 °C

Boiling Point: 638.4 °C at 760 mmHg

Flash Point:339.9 °C

Solubility:H2O: 1 mg/mL, clear, colorless

Storage Temp.:Store at RT

Vapor Pressure: 3.4E-16mmHg at 25°C

Merck: 14,7717

BRN: 4303561

PSA: 106.95000

LogP: 3.17070

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