- Novel protection-deprotection strategies in diazeniumdiolate chemistry: Synthesis of V-IPA/NO
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Synthesis of previously inaccessible, potentially liver selective HNO donor V-IPA/NO ([iPrHN3-N1(O1)N2-O 2-R], where R = vinyl) is reported here. A novel fluoride-labile TOM group at O-2 in conjunctio
- Nandurdikar, Rahul S.,Keefer, Larry K.,Saavedra, Joseph E.
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- Drug and Imaging Agent Delivery Compositions and Methods
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A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical polymerization techniques, including reversible addition-fragmentation chain transfer and macromolecular design via the interchange of xanthates with a broad range of reaction conditions and functional groups. The star-shaped polymeric carriers can be tailored for preferential delivery of chemotherapeutics into the tumor-draining lymphatics via subcutaneous, peritumoral or intratumoral injections. The carriers can be loaded with the chemotherapeutic agents from about 10% to about 25% w/w. In addition, the carriers can be loaded with imaging agents from about 5% to about 10% w/w. The molecular weights of the polymeric carriers can be about 40 kDa to about 130 kDa. The chemotherapeutics can be cisplatin, geldanamycin or nitric oxide-donating prodrugs. The imaging agent can be a near-infrared dye, such as IR820.
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Paragraph 0122
(2013/07/31)
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