205432-12-8 Usage
Biochem/physiol Actions
JS-K belongs to the class of diazeniumdiolate prodrug. It generates nitric oxide when metabolized by glutathione S-transferases (GST), which ensures optimal activity of JS-K. It has tumor growth inhibition action in human prostate cancer and leukemia.
Check Digit Verification of cas no
The CAS Registry Mumber 205432-12-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,4,3 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 205432-12:
(8*2)+(7*0)+(6*5)+(5*4)+(4*3)+(3*2)+(2*1)+(1*2)=88
88 % 10 = 8
So 205432-12-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H16N6O8/c1-2-26-13(20)15-5-7-16(8-6-15)19(25)14-27-12-4-3-10(17(21)22)9-11(12)18(23)24/h3-4,9H,2,5-8H2,1H3/b19-14-
205432-12-8Relevant articles and documents
Novel protection-deprotection strategies in diazeniumdiolate chemistry: Synthesis of V-IPA/NO
Nandurdikar, Rahul S.,Keefer, Larry K.,Saavedra, Joseph E.
, p. 6710 - 6712 (2011)
Synthesis of previously inaccessible, potentially liver selective HNO donor V-IPA/NO ([iPrHN3-N1(O1)N2-O 2-R], where R = vinyl) is reported here. A novel fluoride-labile TOM group at O-2 in conjunctio
