- 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES
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Compounds of formula (I) for use in the treatment or prophylaxis of a disease, which is a hyperproliferative disease and/or a disorder responsive to induction of cell death, selected from a haematological tumour, a solid tumour and/or metastases thereof, said tumour harbouring a mutant EGFR with exon 19 or 21 mutations, and their use as pharmaceuticals.
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Page/Page column 93-94
(2020/11/03)
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- 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES
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Compounds of formula (I) processes for their production and their use as pharmaceuticals.
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Page/Page column 84
(2019/05/15)
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- Proline catalyzed sequential α-aminooxylation or -amination/reductive cyclization of o-nitrohydrocinnamaldehydes: A high yield synthesis of chiral 3-substituted tetrahydroquinolines
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A new sequential organocatalytic method for the synthesis of chiral 3-substituted (X = OH, NH2) tetrahydroquinoline derivatives (THQs) [ee up to 99%, yield up to 87%] based on α-aminooxylation or -amination followed by reductive cyclization of o-nitrohydrocinnamaldehydes has been described. This methodology has been efficiently demonstrated in the synthesis of two important bioactive molecules namely (-)-sumanirole (96% ee) and 1-[(S)-3-(dimethylamino)-3,4-dihydro-6,7-dimethoxy-quinolin-1(2H)-yl]propanone (92% ee). The Royal Society of Chemistry 2013.
- Rawat, Varun,Kumar, B. Senthil,Sudalai, Arumugam
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supporting information
p. 3608 - 3611
(2013/06/26)
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- Cobalt(II) chloride hexahydrate-diisopropylamine catalyzed mild and chemoselective reduction of carboxylic esters with sodium borohydride
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The cobalt-catalyzed reduction of unsaturated α-cyano carboxylic esters using sodium borohydride (NaBH4) leads to the corresponding saturated cyano alcohols in high yields. In particular, the new catalytic system cobalt(II) chloride-diisopropylamine in combination with NaBH4 showed excellent activity in the chemoselective reduction of a variety of carboxylic esters to their corresponding alcohols in good to excellent yields under mild conditions. Georg Thieme Verlag Stuttgart.
- Jagdale, Arun R.,Paraskar, Abhimanyu S.,Sudalai, Arumugam
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experimental part
p. 660 - 664
(2009/07/03)
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- Wilkinson's catalyst catalyzed selective hydrogenation of olefin in the presence of an aromatic nitro function: A remarkable solvent effect
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Optimal conditions for chlorotris(triphenylphosphine)rhodium(I) (Wilkinson's catalyst) catalyzed selective saturation of a double bond in the presence of a nitro function are developed. Aryl iodide and benzyl ether are also tolerated under these hydrogenation conditions.
- Jourdant, Angelique,Gonzalez-Zamora, Eduardo,Zhu, Jieping
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p. 3163 - 3164
(2007/10/03)
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