Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes
We report the discovery of a new bioorthogonal click-and-release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiological conditions. Optimized iminosydnones were successfully used to design innovative cleavable linkers for protein modification, thus opening up new areas in the fields of drug release and target-fishing applications. This click-and-release technology offers the possibility of exchanging tags on proteins for functionalized cyclooctynes under mild and bioorthogonal conditions.
Colorimetric Naphthalene-Based Thiosemicarbazide Anion Chemosensors with an Internal Charge Transfer Mechanism
A series of thiosemicarbazide anion chemosensors substituted with naphthalene and 4-nitrophenyl or phenyl units were synthesized. The molecules were characterized by using1H,13C DEPT and15N NMR spectroscopy. The anion bind
Farrugia, Kristina N.,Makuc, Damjan,Podborska, Agnieszka,Szaci?owski, Konrad,Plavec, Janez,Magri, David C.
supporting information
p. 4415 - 4422
(2016/09/14)
More Articles about upstream products of 2078-93-5