- PRODUCTION METHOD OF 2,3-DIHALOGENOANILINE
-
PROBLEM TO BE SOLVED: To provide a production method of 2,3-dihalogenoaniline in a high yield without high-temperature, high-pressure reaction conditions. SOLUTION: A production method of 2,3-dihalogenoaniline includes a step of substituting the 3-halogeno group of a 1,2,3-trihalogeno-4-nitrobenzene with an amino group to obtain 2,3-dihalogeno-6-nitroaniline, making succinic acid to act on the amino group so as to obtain 1-(2,3-dihalogeno-6-nitrophenyl)pyrrolidin-2,5-dione, reducing the 6-nitro group of the obtained 1-(2,3-dihalogeno-6-nitrophenyl)pyrrolidin-2,5-dione to convert into 6-amino group so as to obtain 1-(2,3-dihalogeno-6-aminophenyl)pyrrolidin-2,5-dione (formula (IV)) and reducing the 6-amino group to cleave 2,5-dioxo-1-pyrrolidinyl group so as to induce to an amino group. COPYRIGHT: (C)2016,JPOandINPIT
- -
-
Paragraph 0033; 0034
(2016/10/07)
-
- Fluorinated 2-Amino-4-(Benzylamino)Phenylcarbamate Derivatives
-
The invention relates to fluorinated compounds and their use as anti-epileptic, muscle-relaxing, fever-reducing and peripherally analgesically acting medications and as imaging agents. Novel fluorinated 2-amino-4-(benzylamino)phenyl carbamate derivatives of ezogabine and pharmaceutically acceptable salts or solvates thereof and their use are described.
- -
-
Paragraph 0135; 0136
(2013/11/06)
-
- SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF
-
The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.
- -
-
Page/Page column 96-97, 119-120
(2010/04/03)
-
- Benzimidazole derivatives for the treatment of viral infections
-
According to a first aspect of the invention there is provided compounds of formula (I): wherein: R1is hydroxy; O-acetyl; or a halo atom; R2is hydroxy; O-acetyl; or a halo atom; R3is hydrogen; a halo atom; azido; C2-6alkenyl; C2-6alkynyl; C6-14aryl C2-6alkenyl; C6-14arylC2-6alkynyl —NR8R9(where R8and R9may be the same or different and are hydrogen, C1-8alkyl, cyanoC1-8alkyl, hydroxyC1-8alkyl, haloC1-8alkyl, C3-7cycloalkyl, C1-8alkylC3-7cycloalkyl, C2-6alkenyl, C3-7cycloalkylC1-8alkyl, C2-6alkynyl, C6-14aryl, C6-14arylC1-8alkyl, heterocycleC1-8alkyl, C1-8alkylcarbonyl, C6-14arylsulfonyl, C1-8alkysulfonyl, or R8R9together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); —OR10(where R10is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl, C2-6alkenyl, C2-6alkynyl, C6-14aryl C2-6alkenyl or C6-14arylC2-6alkynyl); or —SR11(where R11is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl).
- -
-
-