- Dithioacetal-containing naphthalene derivative, preparation method and application of naphthalene derivative and medicine prepared from naphthalene derivative
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The invention discloses a dithioacetal-containing naphthalene derivative and a preparation method and application thereof. The structural formula of the derivative is shown as (1) in the description,wherein in the formula, R1 is methyl groups or methoxy groups or halogen atoms or hydrogen atoms, and the halogen atoms are fluorine or chlorine or bromine, and R2 is substituted benzene rings or propargyl groups or hydroxyethyl groups. The dithioacetal-containing naphthalene derivative has high activity on the cucumber mosaic virus disease and the tobacco mosaic virus disease, especially on the cucumber mosaic virus disease, and the compound also has high activity on the bacterial blight of rice; besides, the preparation method high in yield and low in production cost.
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Paragraph 0038; 0048; 0053; 0054
(2019/04/30)
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- Facile synthesis of novel dithioacetal-naphthalene derivatives as potential activators for plant resistance induction
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In this paper, a series of novel dithioacetal-naphthalenes were designed and synthesized for plant immunity. Their antiviral activities were evaluated against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). The results indicated that most compounds exhibited better activity against CMV than against TMV. These dithioacetal derivatives also displayed good bacterial activity against rice bacterial leaf blight. Among them, compound S16 exhibited relatively good anti-CMV, anti-TMV, and antibacterial activity. Structure-activity relationships indicated that introducing the naphthalene moiety enhanced their activities for plant resistance induction. Therefore, the basic motif of compound S16 could be the most promising candidate for further structural optimization to develop a potential activator for plant resistance induction.
- Ji,Shi,Tian,Zhang,Wang
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p. 32375 - 32381
(2019/10/23)
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- PROPHYLACTIC OR THERAPEUTIC AGENT FOR CANCER
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A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has a superior activity as an estrogen-related receptor-α modulator, and is useful as a prophylactic or therapeutic agent for cancer.
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Page/Page column 57-58
(2012/05/20)
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