- Method for treating emesis with ghrelin agonists
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The present invention relates to a method comprising administering to a patient diagnosed as being in need of treatment for nausea, emesis, or symptoms associated therewith comprising administering to a patient in need thereof a compound of formula (I) wh
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Page/Page column 5
(2010/02/15)
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- Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats
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LY444711 is an orally active ghrelin agonist that binds with good affinity and is a potent activator of the growth hormone secretagogue receptor 1a (GHS-R1a) receptor. In rat models of feeding behavior and pharmacology, LY444711 creates a positive energy
- Lugar, Charles W.,Clay, Michael P.,Lindstrom, Terry D.,Woodson, Andrea L.,Smiley, David,Heiman, Mark L.,Dodge, Jeffrey A.
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p. 5873 - 5876
(2007/10/03)
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- Growth hormone secretagogues
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What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C6H5CH2OCH2—, C6H5(CH2)3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1to C6alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6alkoxy or phenyl; and R4 is H or CH3, or a pharmaceutically acceptable salt or solvate thereof.
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Page column 29-30
(2010/02/09)
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