220529-51-1Relevant articles and documents
Method for treating emesis with ghrelin agonists
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Page/Page column 5, (2010/02/15)
The present invention relates to a method comprising administering to a patient diagnosed as being in need of treatment for nausea, emesis, or symptoms associated therewith comprising administering to a patient in need thereof a compound of formula (I) wh
Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats
Lugar, Charles W.,Clay, Michael P.,Lindstrom, Terry D.,Woodson, Andrea L.,Smiley, David,Heiman, Mark L.,Dodge, Jeffrey A.
, p. 5873 - 5876 (2007/10/03)
LY444711 is an orally active ghrelin agonist that binds with good affinity and is a potent activator of the growth hormone secretagogue receptor 1a (GHS-R1a) receptor. In rat models of feeding behavior and pharmacology, LY444711 creates a positive energy