Chiral 1,2,3,4-tetrahydroquinolinyl-oxazoline ligands for Ru-catalyzed asymmetric transfer hydrogenation of ketones
Chiral 1,2,3,4-tetrahydroquinolinyl-oxazoline compounds have been synthesized from 8-quinolinecarboxylic acid and enantiomerically pure amino alcohols using a convenient procedure. Asymmetric transfer hydrogenation of aryl ketones with the catalyst prepared in situ from [Ru(p-cymene)Cl2]2 and ligands 2 in 2-propanol in the presence of KOH, afforded the corresponding secondary alcohols in reasonable yields and up to 83% e.e.
Chiral quinolinyl-oxazolines as ligands for copper(I)-catalyzed asymmetric cyclopropanation
Chiral quinolinyl-oxazoline compounds have been synthesized from enantiomerically pure amino alcohols and 8-quinoline-carboxylic acid using a convenient procedure. Asymmetric cyccopropanation of styrene with diazoacetates in the presence of 1 mol% of CuOTf and quinolinyl-oxazolines gave 2-phenylcyclopropane carboxylates in moderate enantiomeric excesses.
Wu, Xin-Yan,Li, Xiang-Hong,Zhou, Qi-Lin
p. 4143 - 4150
(2007/10/03)
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