A quinoline derivative represented by the following formula (1): allows PPARα or γ which is an intranuclear transcription factor, to function strongly and is low in toxicity. By using this compound as an active ingredient, there can be provided a preventive or therapeutic agent for various diseases related to PPARα or γ.
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(2008/06/13)
Chiral 1,2,3,4-tetrahydroquinolinyl-oxazoline ligands for Ru-catalyzed asymmetric transfer hydrogenation of ketones
Chiral 1,2,3,4-tetrahydroquinolinyl-oxazoline compounds have been synthesized from 8-quinolinecarboxylic acid and enantiomerically pure amino alcohols using a convenient procedure. Asymmetric transfer hydrogenation of aryl ketones with the catalyst prepared in situ from [Ru(p-cymene)Cl2]2 and ligands 2 in 2-propanol in the presence of KOH, afforded the corresponding secondary alcohols in reasonable yields and up to 83% e.e.