FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: Preparation of selected API impurities
There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time. This journal is
Gangadurai, Chinnakuzhanthai,Illa, Giri Teja,Reddy, D. Srinivasa
p. 8459 - 8466
(2020/11/05)
The effect of humidity on the stability of diclofenac sodium in inclusion complex with β-cyclodextrin in the solid state
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Hladon, Teresa,Cwiertnia
p. 943 - 944
(2007/10/03)
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