22121-58-0

Basic information

• Product Name: 2-(2,6-Dichloroanilino) benzaldehyde
• Synonyms: 2-(2,6-Dichloroanilino) benzaldehyde;N-(2,6-Dichlorophenyl)anthranilaldehyde;o-(2,6-Dichloroanilino)benzaldehyde;2-[(2,6-Dichlorophenyl)aMino]benzaldehyde (Diclofenac iMpurity);Diclofenac IMpurity-B(EP/BP);Diclofenac EP Impurity B;Diclofenac sodium impurity A
• CAS NO: 22121-58-0
• Molecular Formula: C₁₃H₉Cl₂NO
• Molecular Weight: 266.12
• Product Categories: Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 22121-58-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 112-114?C
• Boiling Point: 349.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.392±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated
• PKA: -4.46±0.50(Predicted)
• CAS DataBase Reference: 2-(2,6-Dichloroanilino) benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-Dichloroanilino) benzaldehyde(22121-58-0)
• EPA Substance Registry System: 2-(2,6-Dichloroanilino) benzaldehyde(22121-58-0)

Safety Data

• Hazardous Substances Data: 22121-58-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 22121-58-0 differently. You can refer to the following data:
1. An impurity of Diclofenac (D436450)
2. 2-[(2,6-Dichlorophenyl)amino]benzaldehyde (Diclofenac EP Impurity B) is an impurity of Diclofenac (D436450).
3. Diclofenac impurity. Anti-inflammatory

Upstream product

• 15307-79-6 diclofenac sodium 
• 67-56-1 methanol 

Relevant articles and documents

FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: Preparation of selected API impurities

There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time. This journal is