- MACROHETEROCYCLES. 12. SYNTHESIS AND PROPERTIES OF MACROCYCLIC TETRAAMIDES
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The N,N'-bis(methoxycarbonylmethyl)diamides of the corresponding acids were obtained by the reaction of glycine methyl ester hydrochloride with oxalic, succinic, adipic, diglycolic, and triglycolic acid dichlorides.Fourteen new macrocyclic tetraamides were obtained by the reaction of these diamides with various diamines.The structures of the synthesized compounds were proved by means of their IR, PMR, and mass spectra.
- Luk'yanenko, N. G.,Bogat-skii, A. V.,Popkov, Yu. A.
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- Effective stabilisation of α-helical structures in short peptides with acetylenic cross-linking agents
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The peptides cross-linked by the acetylenic cross-linking agents showed high α-helical contents, and the α-helices thus formed survived up to substantially elevated temperature.
- Fujimoto, Kazuhisa,Oimoto, Natsuko,Katsuno, Kahori,Inouye, Masahiko
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Read Online
- Reactions of peroxide products of ozonolysis of allyl ethers/esters in the AcOH-CH2Cl2 system on treatment with semicarbazide hydrochloride
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Background: A one-pot method for the preparation of the corresponding alkoxy acetic acids by low-temperature ozonolysis of allyl ethers/esters followed by treatment with semicarbazide hydrochloride has been suggested. The reaction occurs via formation of acetoxyhydroperoxide, subsequent reduction of which depends on the process temperature and the nature of the starting substrate. Objective: The article is aimed at the development of one-pot method for obtaining practically important alkoxy acetic acids, because the ozonolytic cleavage of a ?=? double bond is the key step in full syntheses of many biologically active compounds. Methods: We used a low temperature ozonolysis of functionally substituted olefins in the system acetic acid-methylene dichloride followed by reduction of semicarbazide hydrochloride. To create a method we have used available allyl ethers/esters as starting materials. Results: We investigated reaction of the peroxide products of ozonolysis of monoallyl ethers, ester and diallyl ethers in an AcOH/CH2Cl2 mixture on treatment with semicarbazide hydrochloride at various temperatures. We have discovered that the selectivity of reduction of acetoxyhydroperoxide formed at the first stage depends both on the process temperature and on the nature of the starting substrate. A decrease in temperature favors acid hydrolysis and formation of a carboxylic acid. Conclusion: We have proposed a simple and highly efficient one-pot method for the preparation alkoxy acetic acids without isolation of intermediate peroxides.
- Raskil'dina, Gulnara Z.,Legostaeva, Yuliya V.,Garifullina, Liliya R.,Sultanova, Rimma M.,Ishmuratov, Gumer Y.,Zlotskii, Simon S.
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p. 652 - 656
(2017/01/13)
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- Ether acid copper complex monocrystal, and preparation method and application thereof
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The invention discloses an ether acid copper complex monocrystal. The structure of the monocrystal is [Cu(L)(H2O)2], wherein L is ethyldioxydiacetic acid. The invention also discloses a preparation method of the monocrystal. The method adopts a normal temperature volatilization technology, and concretely comprises the following steps: stirring the L and Cu(Ac)2.H2O in water for 0.5h, filtering the obtained solution, and volatilizing the obtained filtrate at normal temperature for 2 weeks in order to obtain the blue block crystal suitable for X-ray single crystal diffraction, wherein a molar ratio of the L to Cu(Ac)2.H2O is 1:1. The invention further discloses an application of the ether acid copper complex monocrystal in detection of the adsorption quantity of a dye or a luminescence agent as a potential fluorescent material.
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Paragraph 0018; 0019
(2016/10/10)
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- Selective recovery of rare earth elements using chelating ligands grafted on mesoporous surfaces
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Nowadays, rare earth elements (REEs) and their compounds are critical for the rapidly growing advanced technology sectors and clean energy demands. However, their separation and purification still remain challenging. Among different extracting agents used for REE separation, the diglycolamide (DGA)-based materials have attracted increasing attention as one of the most effective extracting agents. In this contribution, a series of new and element-selective sorbents were generated through derivatisation of the diglycolamide ligand (DGA), grafted to mesoporous silica and tested for the separation of rare earth elements. It is shown that, by tuning the ligand bite angle and its environment, it is possible to improve the selectivity towards specific rare earth elements.
- Florek, Justyna,Mushtaq, Ambreen,Larivière, Dominic,Cantin, Gabrielle,Fontaine, Frédéric-Georges,Kleitz, Freddy
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p. 103782 - 103789
(2015/12/24)
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- NEAR-INFRARED-RAY-ABSORBING COMPOSITION, NEAR-INFRARED-RAY CUT FILTER USING SAME, MANUFACTURING METHOD THEREFOR, CAMERA MODULE, AND MANUFACTURING METHOD THEREFOR
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Provided are a near-infrared-ray-absorbing composition having strong near-infrared shielding properties when a cured film is produced, a near-infrared-ray cut filter, a manufacturing method therefor, a camera module, and a manufacturing method therefor. The near-infrared-ray-absorbing composition includes a copper complex obtained by reacting a compound (A) having at least two coordination sites with a copper component.
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Paragraph 0908; 0910; 0911
(2017/01/02)
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- Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma
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We here report the synthesis of ethylene glycol N-interlinked imipramine dimers of various lengths from the tricyclic antidepressant desipramine via an amide coupling reaction followed by reduction with lithium aluminium hydride. The target molecules were found to be potent inhibitors of cellular viability while inducing cell type specific death mechanisms in three cancer cell lines including a highly chemoresistant Burkitt's lymphoma cell line. Basic amine analogues were found to be important for increased potency. Imipramine and desipramine were also tested for apoptotic activity and were found to be much less active than the novel dimeric compounds. Imipramine dimers were only found to be moderate inhibitors of the human serotonin transporter (hSERT) having IC50 values in the micromolar region whilst the induction of cell death occurred independently of hSERT expression. These results demonstrate the potential of newly designed and synthesised imipramines derivatives for use against malignant cells, including those resistant to standard chemotherapy.
- Bright, Sandra A.,Brink?, Anne,Larsen, Maja Thim,Sinning, Steffen,Williams, D. Clive,Jensen, Henrik H.
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supporting information
p. 1220 - 1224
(2013/03/14)
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- Design, synthesis, and properties of neoglycolipids based on ethylene glycoles conjugated with lactose as components of targeted delivery systems of biologically active compounds
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Synthesis has been developed of a series of new aliphatic lactose derivatives as components of liposomal targeted delivery systems distinguished by the length and the number of aliphatic chains and also by the length of the spacer fragment. The structure of compounds synthesized has been established by means of 1H NMR spectroscopy. Pleiades Publishing, Ltd., 2012.
- Gur'eva,Bol'sheborodova,Sebyakin
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p. 1047 - 1054
(2013/01/15)
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- CYTOSOLIC FLUORESCENT ION INDICATORS
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Novel fluorophores for fluorescent ion indicators incorporate water-solubilizing functional groups. These fluorophores enable visible-wavelength analysis of ion concentrations with chelators that are insoluble or poorly soluble in water. A green version of the fluorophore comprises a putative fluorescein with carboxylate appendages. An orange version of the fluorophore comprises a putative rhodamine, also with carboxylate appendages. Attaching the fluorophore to a 12-crown-4, a 15-crown-5, a 18-crown-6, a 21-crown-7, or a 24-crown-8 produces lithium, sodium, potassium, rubidium, and cesium indicator families, respectively. Attaching the fluorophore to diaza [1,1,1], [1,1,2], [1,2,2], [2,2,2], [2,2,3], [2,3,3], or [3,3,3] cryptands produces more selective lithium, sodium, potassium, rubidium, and cesium indicator families, respectively. Attaching the fluorophore to BAPTA, APTRA, or half- BAPTA or their analogs produces new calcium, magnesium, and other metal ions indicator families that strongly resist leakage from the cell.
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Page/Page column 29
(2012/04/10)
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- Electroorganic synthesis in oil-in-water (O/W) nanoemulsion: TEMPO-mediated electrooxidation of amphiphilic alcohols in water
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Oil-in-water nanoemulsion which consisted of TEMPO, amphiphilic alcohols, and water offered unique reaction environments for electrooxidation of the alcohols to give the corresponding carboxylic acids in good to excellent yields.
- Kuroboshi, Manabu,Yoshida, Tomonori,Oshitani, Jun,Goto, Kuniaki,Tanaka, Hideo
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experimental part
p. 7177 - 7185
(2009/12/24)
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- Electroorganic synthesis in oil-in-water nanoemulsion: TEMPO-mediated electrooxidation of amphiphilic alcohols in water
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Oil-in-water nanoemulsions, consisting of TEMPO, amphiphilic alcohols, and water, offer unique reaction environments for electrooxidation of the alcohols to give the corresponding carboxylic acids in good to excellent yields. Georg Thieme Verlag Stuttgart.
- Yoshida, Tomonori,Kuroboshi, Manabu,Oshitani, Jun,Gotoh, Kuniaki,Tanaka, Hideo
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p. 2691 - 2694
(2008/02/12)
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- OXIDATION OF ALCOHOLS BY ELECTROCHEMICALLY REGENERATED NICKEL OXIDE HYDROXIDE. SELECTIVE OXIDATION OF HYDROXYSTEROIDS
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Primary alcohols, α,ω-diols and secondary alcohols are easily transformed into carboxylic acids, dicarboxylic acids or ketones, respectively, by heterogeneous oxidation with nickel oxide hydroxide electrochemically regenerated at a nickel hydroxyde electrode.The results are discussed in comparison to those of the nickel peroxide and chromic acid oxidation.The oxidation rate decreases with increasing steric hindrance of the alcohol, thus allowing the selective oxidation of the 3-position in hydroxysteroids.
- Kaulen, Johannes,Schaefer, Hans-J.
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p. 3299 - 3308
(2007/10/02)
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- Kinetics of Ru(III) Chloride Catalysed Oxidation of Di- and Tri-ethylene Glycols by Hexacyanoferrate(III)
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Kinetics of the title reactions in aq. alkaline medium and at constant ionic strength are reported.The oxidation reaction follows complex kinetics, the order being zero with respect to initial , nearly unity with respect to low concentration of substrates and zero at higher .The rate of reaction is inversely proportional to .A suitable mechanism involving the hydride ion transfer from the α-carbon atom of glycol by ruthenium(III) complex has been suggested.
- Singh, H. S.,Tiwari, K. C.,Singh, S. M.
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p. 520 - 522
(2007/10/02)
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- CHIRAL AMINOACID CONTAINING ACYCLIC LIGANDS-I. SYNTHESES AND CONFORMATIONS
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Synthesis and spectral properties of optically active acyclic ligands, containing two (S)-phenylalanine residues (3a-f) are described.The synthesis is achieved by two different routes.Conformational studies in different solvents are performed by dilution and temperature-dependent experiments of 1H and 13C NMR spectroscopy.
- Lodi, T.,Marchelli, R.,Dossena, A.,Dradi, E.,Casnati, G.
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p. 2055 - 2060
(2007/10/02)
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- Complexes of macrocyclic compounds
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Novel macrocyclic (monocyclic and bicyclic) compounds having nitrogen bridgehead atoms and having in the hydrocarbon bridging chains at least two additional hetero atoms selected from the group consisting of sulfur, oxygen, and nitrogen, when admixed with a compatible cation-donor compound form stable cation-containing macrocyclic complexes which, in turn, can be conveniently dissociated by addition of acid or a quaternizing agent. The novel macrocyclics are valuable for use in the same way and for the same purposes as chelating agents.
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