23243-68-7Relevant articles and documents
MACROHETEROCYCLES. 12. SYNTHESIS AND PROPERTIES OF MACROCYCLIC TETRAAMIDES
Luk'yanenko, N. G.,Bogat-skii, A. V.,Popkov, Yu. A.
, p. 847 - 852 (1981)
The N,N'-bis(methoxycarbonylmethyl)diamides of the corresponding acids were obtained by the reaction of glycine methyl ester hydrochloride with oxalic, succinic, adipic, diglycolic, and triglycolic acid dichlorides.Fourteen new macrocyclic tetraamides were obtained by the reaction of these diamides with various diamines.The structures of the synthesized compounds were proved by means of their IR, PMR, and mass spectra.
Reactions of peroxide products of ozonolysis of allyl ethers/esters in the AcOH-CH2Cl2 system on treatment with semicarbazide hydrochloride
Raskil'dina, Gulnara Z.,Legostaeva, Yuliya V.,Garifullina, Liliya R.,Sultanova, Rimma M.,Ishmuratov, Gumer Y.,Zlotskii, Simon S.
, p. 652 - 656 (2017/01/13)
Background: A one-pot method for the preparation of the corresponding alkoxy acetic acids by low-temperature ozonolysis of allyl ethers/esters followed by treatment with semicarbazide hydrochloride has been suggested. The reaction occurs via formation of acetoxyhydroperoxide, subsequent reduction of which depends on the process temperature and the nature of the starting substrate. Objective: The article is aimed at the development of one-pot method for obtaining practically important alkoxy acetic acids, because the ozonolytic cleavage of a ?=? double bond is the key step in full syntheses of many biologically active compounds. Methods: We used a low temperature ozonolysis of functionally substituted olefins in the system acetic acid-methylene dichloride followed by reduction of semicarbazide hydrochloride. To create a method we have used available allyl ethers/esters as starting materials. Results: We investigated reaction of the peroxide products of ozonolysis of monoallyl ethers, ester and diallyl ethers in an AcOH/CH2Cl2 mixture on treatment with semicarbazide hydrochloride at various temperatures. We have discovered that the selectivity of reduction of acetoxyhydroperoxide formed at the first stage depends both on the process temperature and on the nature of the starting substrate. A decrease in temperature favors acid hydrolysis and formation of a carboxylic acid. Conclusion: We have proposed a simple and highly efficient one-pot method for the preparation alkoxy acetic acids without isolation of intermediate peroxides.
Selective recovery of rare earth elements using chelating ligands grafted on mesoporous surfaces
Florek, Justyna,Mushtaq, Ambreen,Larivière, Dominic,Cantin, Gabrielle,Fontaine, Frédéric-Georges,Kleitz, Freddy
, p. 103782 - 103789 (2015/12/24)
Nowadays, rare earth elements (REEs) and their compounds are critical for the rapidly growing advanced technology sectors and clean energy demands. However, their separation and purification still remain challenging. Among different extracting agents used for REE separation, the diglycolamide (DGA)-based materials have attracted increasing attention as one of the most effective extracting agents. In this contribution, a series of new and element-selective sorbents were generated through derivatisation of the diglycolamide ligand (DGA), grafted to mesoporous silica and tested for the separation of rare earth elements. It is shown that, by tuning the ligand bite angle and its environment, it is possible to improve the selectivity towards specific rare earth elements.
Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma
Bright, Sandra A.,Brink?, Anne,Larsen, Maja Thim,Sinning, Steffen,Williams, D. Clive,Jensen, Henrik H.
supporting information, p. 1220 - 1224 (2013/03/14)
We here report the synthesis of ethylene glycol N-interlinked imipramine dimers of various lengths from the tricyclic antidepressant desipramine via an amide coupling reaction followed by reduction with lithium aluminium hydride. The target molecules were found to be potent inhibitors of cellular viability while inducing cell type specific death mechanisms in three cancer cell lines including a highly chemoresistant Burkitt's lymphoma cell line. Basic amine analogues were found to be important for increased potency. Imipramine and desipramine were also tested for apoptotic activity and were found to be much less active than the novel dimeric compounds. Imipramine dimers were only found to be moderate inhibitors of the human serotonin transporter (hSERT) having IC50 values in the micromolar region whilst the induction of cell death occurred independently of hSERT expression. These results demonstrate the potential of newly designed and synthesised imipramines derivatives for use against malignant cells, including those resistant to standard chemotherapy.
