- Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H2O2
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An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H2O2 in MeOH or CH3CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent.
- Adrio, Javier,Amarante, Giovanni Wilson,Granato, álisson Silva
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p. 13817 - 13823
(2021/10/01)
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- Molybdenum oxide/bipyridine hybrid material {[MoO3(bipy)] [MoO3(H2O)]}n as catalyst for the oxidation of secondary amines to nitrones
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The inorganic-organic hybrid material {[MoO3(bipy)][MoO 3(H2O)]}n (bipy = 2,2′-bipyridine) can be used as a water-tolerant catalyst for the oxidation of secondary amines under mild conditions using either urea hydrogen peroxide (UHP) or tert-butylhydroperoxide (TBHP) as the oxidant. Under optimized reaction conditions (2 mol % catalyst, 3-4 equiv TBHP, CH2Cl2 as the solvent, 40 °C), the corresponding nitrones were obtained with different efficiency depending on the nature of the cyclic or acyclic amine used.
- Abrantes, Marta,Gonalves, Isabel S.,Pillinger, Martyn,Vurchio, Carolina,Cordero, Franca M.,Brandi, Alberto
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experimental part
p. 7079 - 7082
(2012/01/30)
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