- Gold nanoparticles supported on magnesium oxide nanorods for oxidation of alcohols
-
Gold nanoparticles supported on magnesium oxide nanorods (Au-MgO) have been synthesised by a solution based chemical reduction method. Au-MgO nanorods were found to be an efficient heterogeneous catalyst for oxidation of alcohols with hydrogen peroxide in aqueous medium at room temperature. To find out the best reaction conditions for oxidation, optimization of catalyst quantity, solvent, mole equivalence of hydrogen peroxide were carried out. The scope of the reaction was extended to several aromatic and aliphatic alcohols, product yields were quantified by gas chromatography (GC) and GC/mass spectroscopy. Heterogeneity and reusability tests were performed. The use of water as a solvent and hydrogen peroxide as co-catalyst at room temperature makes the reaction interesting from sustainable development point of view.
- Emayavaramban,Ganesh Babu,Karvembu,Kadirvelu,Dharmaraj
-
-
Read Online
- Molybdenum tricarbonyl complex functionalised with a molecular triazatriangulene platform on Au(111): Surface spectroscopic characterisation
-
Transition metal complexes form the basis for small molecule activation and are relevant for electrocatalysis. To combine both approaches the attachment of homogeneous catalysts to metallic surfaces is of significant interest. Towards this goal a molybdenum tricarbonyl complex supported by a tripodal phosphine ligand was covalently bound to a triazatriangulene (TATA) platform via an acetylene unit and the resulting TATA-functionalised complex was deposited on a Au(111) surface. The corresponding self-assembled monolayer was characterised with scanning tunnelling microscopy (STM), X-ray photoelectron spectroscopy (XPS), and near-edge X-ray absorption fine structure (NEXAFS). The vibrational properties of the surface-adsorbed complexes were investigated with the help of infrared reflection absorption spectroscopy (IRRAS), and the frequency/intensity changes with respect to the bulk spectrum were analysed. A full vibrational analysis was performed with the help of DFT.
- Petersen, Finn,Lautenschl?ger, Irene,Schlimm, Alexander,Fl?ser, Benedikt M.,Jacob, Hanne,Amirbeigiarab, Reihaneh,Rusch, Talina R.,Strunskus, Thomas,Magnussen, Olaf,Tuczek, Felix
-
-
Read Online
- Aerobic epoxidation of styrene over Zr-based metal-organic framework encapsulated transition metal substituted phosphomolybdic acid
-
Catalytic epoxidation of styrene with molecular oxygen is regarded as an eco-friendly alternative to producing industrially important chemical of styrene oxide (STO). Recent efforts have been focused on developing highly active and stable heterogeneous catalysts with high STO selectivity for the aerobic epoxidation of styrene. Herein, a series of transition metal monosubstituted heteropolyacid compounds (TM-HPAs), such as Fe, Co, Ni or Cu-monosubstituted HPA, were encapsulated in UiO-66 frameworks (denoted as TM-HPA@UiO-66) by direct solvothermal method, and their catalytic properties were investigated for the aerobic epoxidation of styrene with aldehydes as co-reductants. Among them, Co-HPA@UiO-66 showed relatively high catalytic activity, stability and epoxidation selectivity at very mild conditions (313 K, ambient pressure), that can achieve 82 % selectivity to STO under a styrene conversion of 96 % with air as oxidant and pivalaldehyde (PIA) as co-reductant. In addition, the hybrid composite catalyst can also efficiently catalyze the aerobic epoxidation of a variety of styrene derivatives. The monosubstituted Co atoms in Co-HPA@UiO-66 are the main active sites for the aerobic epoxidation of styrene with O2/PIA, which can efficiently converting styrene to the corresponding epoxide through the activation of the in-situ generated acylperoxy radical intermediate.
- Hu, Dianwen,Song, Xiaojing,Zhang, Hao,Chang, Xinyu,Zhao, Chen,Jia, Mingjun
-
-
- High-Level Production of Phenylacetaldehyde using Fusion-Tagged Styrene Oxide Isomerase
-
An order-of-magnitude improvement in the production of phenylacetaldehyde to 3.37 M (405 g L?1) from the enzymatic isomerisation of styrene oxide was achieved. A small ubiquitin-related modifier (SUMO) tag increases the productivity of the whole-cell biocatalytic system by enhancing the expression of active membrane-bound styrene oxide isomerase (SOI) while retaining enzyme catalytic efficiency and broad natural substrate scope. The isomerisation was performed by using Escherichia coli expressing SUMO-tagged SOI in an organic-aqueous biphasic system to yield 96% of phenylacetaldehyde. (Figure presented.).
- Choo, Joel P. S.,Kammerer, Richard A.,Li, Xiaodan,Li, Zhi
-
p. 1714 - 1721
(2021/02/12)
-
- B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of: In situ -formed enamines
-
A highly efficient B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines in the presence of water and pinacolborane was developed. Regioselective β-deuteration of tertiary amines was achieved with high chemo- and regioselectivity. D2O was used as a readily available and cheap source of deuterium. Mechanistic studies indicated that B(C6F5)3 could activate water to promote the protonation and reduction of enamines. This journal is
- Wu, Rongpei,Gao, Ke
-
supporting information
p. 4032 - 4036
(2021/05/19)
-
- Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine
-
The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chemistry. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with symmetric and unsymmetric o-phenylenediamines. The unforeseen tandem reaction occurred among many possible latent side reactions under chiral phosphoric acid catalysis and affords the corresponding products in moderate yields and regioselectivities, good diastereoselectivities, and enantiomeric ratio (up to 99:1).
- Yang, Gao-Feng,Li, Guang-Xun,Huang, Jin,Fu, Ding-Qiang,Nie, Xiao-Kang,Cui, Xin,Zhao, Jin-Zhong,Tang, Zhuo
-
p. 5110 - 5119
(2021/04/12)
-
- Kinetic Resolution of Neopentylic Secondary Alcohols by Cu-H-Catalyzed Enantioselective Silylation with Hydrosilanes
-
A nonenzymatic kinetic resolution of sterically congested alcohols having a quaternary carbon atom in the β-position is reported. The catalyst system CuCl/NaOtBu/(R,R)-Ph-BPE together with a 3,5-xylyl-substituted tertiary hydrosilane enable enantioselective silylation of the hydroxy group. Several alcohols are obtained with good to excellent selectivity factors, and there are no other known straightforward methods to access these motifs.
- Oestreich, Martin,Papadopulu, Zaneta
-
supporting information
p. 438 - 441
(2021/01/13)
-
- Deoxygenation of Epoxides with Carbon Monoxide
-
The use of carbon monoxide as a direct reducing agent for the deoxygenation of terminal and internal epoxides to the respective olefins is presented. This reaction is homogeneously catalyzed by a carbonyl pincer-iridium(I) complex in combination with a Lewis acid co-catalyst to achieve a pre-activation of the epoxide substrate, as well as the elimination of CO2 from a γ-2-iridabutyrolactone intermediate. Especially terminal alkyl epoxides react smoothly and without significant isomerization to the internal olefins under CO atmosphere in benzene or toluene at 80–120 °C. Detailed investigations reveal a substrate-dependent change in the mechanism for the epoxide C?O bond activation between an oxidative addition under retention of the configuration and an SN2 reaction that leads to an inversion of the configuration.
- Maulbetsch, Theo,Jürgens, Eva,Kunz, Doris
-
p. 10634 - 10640
(2020/07/30)
-
- ANTIMICROBIAL COMPOUNDS AND METHODS
-
The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.
- -
-
Paragraph 00405
(2020/07/31)
-
- Synthesis of Arylacetaldehydes by Iridium-Catalyzed Arylation of Vinylene Carbonate with Arylboronic Acids
-
The one-step synthesis of arylacetaldehydes by carbon–carbon bond formation between formylmethyl and aryl groups has been realized by the reaction of vinylene carbonate with arylboronic acids in the presence of an iridium/bisphosphine catalyst and a catalytic amount of tetrahydroxydiboron.
- Wang, Zhe,Xue, Fei,Hayashi, Tamio
-
supporting information
p. 11054 - 11057
(2019/07/17)
-
- Peroxygenase-Catalysed Epoxidation of Styrene Derivatives in Neat Reaction Media
-
Biocatalytic oxyfunctionalisation reactions are traditionally conducted in aqueous media limiting their production yield. Here we report the application of a peroxygenase in neat reaction conditions reaching product concentrations of up to 360 mM.
- Alcalde, Miguel,Arends, Isabel W. C. E.,Hollmann, Frank,Paul, Caroline E.,Rauch, Marine C. R.,Tieves, Florian
-
-
- Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy
-
Histone lysine demethylases (KDMs) have drawn much attention as targets of therapeutic agents. KDM5 proteins, which are Fe(II)/α-ketoglutarate-dependent demethylases, are associated with oncogenesis and drug resistance in cancer cells, and KDM5-selective inhibitors are expected to be anticancer drugs. However, few cell-active KDM5 inhibitors have been reported and there is an obvious need to discover more. In this study, we pursued the identification of highly potent and cell-active KDM5-selective inhibitors. Based on the reported KDM5 inhibitors, we designed several compounds by strategically merging two fragments for competitive inhibition with α-ketoglutarate and for KDM5-selective inhibition. Among them, compounds 10 and 13, which have a 3-cyano pyrazolo[1,5-a]pyrimidin-7-one scaffold, exhibited strong KDM5-inhibitory activity and significant KDM5 selectivity. In cellular assays using human lung cancer cell line A549, 10 and 13 increased the levels of trimethylated lysine 4 on histone H3, which is a specific substrate of KDM5s, and induced growth inhibition of A549 cells. These results should provide a basis for the development of cell-active KDM5 inhibitors to highlight the validity of our inhibitor-based fragment merging strategy.
- Miyake, Yuka,Itoh, Yukihiro,Hatanaka, Atsushi,Suzuma, Yoshinori,Suzuki, Miki,Kodama, Hidehiko,Arai, Yoshinobu,Suzuki, Takayoshi
-
p. 1119 - 1129
(2019/02/13)
-
- Stereoselective Synthesis of Vinylboronates by Rh-Catalyzed Borylation of Stereoisomeric Mixtures
-
The stereoselective preparation of vinylboronates via rhodium-catalyzed borylation of E/Z mixtures of vinyl actetates is described, and this method was also extended to synthesis of vinyldiboronates. These transformations feature high functional group compatibility and mild reaction conditions. Control experiments support a mechanism that involved a Rh-catalyzed borylation-isomerization sequence. The isomerization of (Z)-vinylboronates to (E)-isomers was also demonstrated.
- Li, Shenhuan,Li, Jie,Xia, Tianlai,Zhao, Wanxiang
-
supporting information
p. 462 - 468
(2019/03/28)
-
- HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS
-
The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): (I), wherein L1, A, X1, X2, R1, R2, and R3 are described herein.
- -
-
Page/Page column 293; 294
(2018/03/25)
-
- Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols
-
A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides.
- Kouser, Farzana,Sharma, Vijay Kumar,Rizvi, Masood,Sultan, Shaista,Chalotra, Neha,Gupta, Vivek K.,Nandi, Utpal,Shah, Bhahwal Ali
-
p. 2161 - 2166
(2018/05/05)
-
- Synthesizing method for oxidizing cobalt and manganese-based composite oxide catalyzed alcohol into aldehyde or ketone
-
The invention discloses a synthesizing method for oxidizing cobalt and manganese-based composite oxide catalyzed alcohol into aldehyde or ketone and belongs to the technical field of aldehyde or ketone synthesis. According to the method, under the action
- -
-
Paragraph 0056; 0057
(2018/07/15)
-
- An efficient oxidation of alcohols by aqueous H2O2 with 1,3-dibromo-5,5-dimethylhydantoin
-
An efficient protocol is described for the oxidation of alcohols to the corresponding aldehydes or ketones with 1,3-dibromo-5,5-dimethylhydantoin in the presence of aqueous H2O2.
- Lee, Jieun,Lee, Jong Chan
-
p. 895 - 898
(2018/11/06)
-
- Manganese-Catalyzed Dual-Deoxygenative Coupling of Primary Alcohols with 2-Arylethanols
-
Reported herein is a general and efficient dual-deoxygenative coupling of primary alcohols with 2-arylethanols catalyzed by a well-defined Mn/PNP pincer complex. This reaction is the first example of the catalytic dual-deoxygenation of alcohols using a non-noble-metal catalyst. Both deoxygenative homocoupling of 2-arylethanols (17 examples) and their deoxygenative cross-coupling with other primary alcohols (20 examples) proceeded smoothly to form the corresponding alkenes by a dehydrogenation and deformylation reaction sequence.
- Wang, Yujie,Shao, Zhihui,Zhang, Kun,Liu, Qiang
-
supporting information
p. 15143 - 15147
(2018/11/01)
-
- CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS
-
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein coupled receptor modulators which may be used as medicaments
- -
-
Paragraph 0477; 0478
(2017/09/21)
-
- Biocatalytic Formal Anti-Markovnikov Hydroamination and Hydration of Aryl Alkenes
-
Biocatalytic anti-Markovnikov alkene hydroamination and hydration were achieved based on two concepts involving enzyme cascades: epoxidation-isomerization-amination for hydroamination and epoxidation-isomerization-reduction for hydration. An Escherichia coli strain coexpressing styrene monooxygenase (SMO), styrene oxide isomerase (SOI), ω-transaminase (CvTA), and alanine dehydrogenase (AlaDH) catalyzed the hydroamination of 12 aryl alkenes to give the corresponding valuable terminal amines in high conversion (many ≥86%) and exclusive anti-Markovnikov selectivity (>99:1). Another E. coli strain coexpressing SMO, SOI, and phenylacetaldehyde reductase (PAR) catalyzed the hydration of 12 aryl alkenes to the corresponding useful terminal alcohols in high conversion (many ≥80%) and very high anti-Markovnikov selectivity (>99:1). Importantly, SOI was discovered for stereoselective isomerization of a chiral epoxide to a chiral aldehyde, providing some insights on enzymatic epoxide rearrangement. Harnessing this stereoselective rearrangement, highly enantioselective anti-Markovnikov hydroamination and hydration were demonstrated to convert α-methylstyrene to the corresponding (S)-amine and (S)-alcohol in 84-81% conversion with 97-92% ee, respectively. The biocatalytic anti-Markovnikov hydroamination and hydration of alkenes, utilizing cheap and nontoxic chemicals (O2, NH3, and glucose) and cells, provide an environmentally friendly, highly selective, and high-yielding synthesis of terminal amines and alcohols.
- Wu, Shuke,Liu, Ji,Li, Zhi
-
p. 5225 - 5233
(2017/08/17)
-
- One-Pot Preparation of C1-Homologated Aliphatic Nitriles from Aldehydes through a Wittig Reaction under Metal-Cyanide-Free Conditions
-
A one-pot protocol to obtain C1-homologated aliphatic nitriles was achieved by treating aromatic and aliphatic aldehydes with the (methoxymethyl)triphenylphosphonium ylide followed by hydrolysis of the resulting methyl vinyl ethers with pTsOH (Ts = para-toluenesulfonyl) and treatment with molecular iodine and aqueous ammonia under metal cyanide free conditions. Neopentyl-type nitriles, which could not be obtained by conventional methods that involved conversion of the neopentyl alcohol into a tosylate and treatment with metal cyanide, were successfully obtained by using the present method.
- Ezawa, Masatoshi,Togo, Hideo
-
p. 2379 - 2384
(2017/05/01)
-
- Maleimide-assisted anti-Markovnikov Wacker-type oxidation of vinylarenes using molecular oxygen as a terminal oxidant
-
Arylacetaldehydes were successfully synthesized by the anti-Markovnikov Wacker-type oxidation of vinylarenes using 1 atm O2 as a terminal oxidant under mild conditions. Electron-deficient alkenes, such as maleic anhydride and maleimides, were effective additives and would operate as ligands to stabilize the Pd(0) species during the reaction.
- Nakaoka, Sonoe,Murakami, Yuka,Kataoka, Yasutaka,Ura, Yasuyuki
-
supporting information
p. 335 - 338
(2016/01/09)
-
- Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties
-
The enzyme 15-lipoxygenase-1 (15-LOX-1) plays a dual role in diseases with an inflammatory component. On one hand 15-LOX-1 plays a role in pro-inflammatory gene expression and on the other hand it has been shown to be involved in central nervous system (CNS) disorders by its ability to mediate oxidative stress and damage of mitochondrial membranes under hypoxic conditions. In order to further explore applications in the CNS, novel 15-LOX-1 inhibitors with favorable physicochemical properties need to be developed. Here, we present Substitution Oriented Screening (SOS) in combination with Multi Component Chemistry (MCR) as an effective strategy to identify a diversely substituted small heterocyclic inhibitors for 15-LOX-1, denoted ThioLox, with physicochemical properties superior to previously identified inhibitors. Ex?vivo biological evaluation in precision-cut lung slices (PCLS) showed inhibition of pro-inflammatory gene expression and in?vitro studies on neuronal HT-22?cells showed a strong protection against glutamate toxicity for this 15-LOX-1 inhibitor. This provides a novel approach to identify novel small with favorable physicochemical properties for exploring 15-LOX-1 as a drug target in inflammatory diseases and neurodegeneration.
- Eleftheriadis, Nikolaos,Poelman, Hessel,Leus, Niek G.J.,Honrath, Birgit,Neochoritis, Constantinos G.,Dolga, Amalia,D?mling, Alexander,Dekker, Frank J.
-
p. 786 - 801
(2016/08/30)
-
- NOVEL COMPOUNDS
-
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.
- -
-
Page/Page column 157
(2016/04/20)
-
- Hypoiodite-catalyzed regioselective oxidation of alkenes: An expeditious access to aldehydes in aqueous micellar media
-
A highly anti-Markovnikov selective oxidation of alkenes based on in situ generated hypoiodite catalysis in aqueous micellar media under mild conditions has been described. This novel catalytic system realizes an efficient synthesis of aldehydes from alkenes in an economically viable and environmentally safe fashion. The preliminary mechanistic studies suggest that the reaction proceeds via tandem iodofunctionalization/1,2-aryl or alkyl migration. The scope and limitations of this tandem process are demonstrated with various mono- and disubstituted (terminal and internal) olefins.
- Swamy, Peraka,Reddy, Marri Mahender,Naresh, Mameda,Kumar, Macharla Arun,Srujana, Kodumuri,Durgaiah, Chevella,Narender, Nama
-
p. 1125 - 1130
(2015/04/22)
-
- DDQ-mediated Direct C(sp3)-H Cyanation of Benzyl Ethers and 1,3-Diarylpropenes under Solvent- and Metal-free Conditions
-
A direct cyanation of benzyl ethers and 1,3-diarylpropenes with TMSCN was performed under solvent- and metal-free conditions. This oxidative cross dehydrative coupling (CDC) reaction was promoted by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and provided rapid access to a broad range of nitriles in good to excellent yields.
- Kong, Shanshan,Zhang, Lingqiong,Dai, Xiaoli,Tao, Lianzhi,Xie, Chunsong,Shi, Lei,Wang, Min
-
supporting information
p. 2453 - 2456
(2015/08/18)
-
- Catalysed anti-Markovnikov oxidation of terminal aryl alkenes to aldehydes and transformation of methyl aryl tertiary amines to formamides with H2O2 as a terminal oxidant
-
Anti-Markovnikov oxidation of terminal aryl alkenes to aldehydes and transformation of N-methyl aryl tertiary amines to formamides with H2O2 as a terminal oxidant under mild conditions have been achieved with moderate to good product yields using [FeIII(TF4DMAP)OTf] as catalyst. This journal is
- Du, Yi-Dan,Tse, Chun-Wai,Xu, Zhen-Jiang,Liu, Yungen,Che, Chi-Ming
-
supporting information
p. 12669 - 12672
(2015/05/20)
-
- Organocatalytic entry into 2,6-disubstituted aza-Achmatowicz piperidinones: Application to (-)-sedacryptine and its epimer
-
Enantiomerically pure 2,6-disubstituted piperidinones were synthesized from furfural involving an organocatalyzed Mannich reaction, aza-Achmatowicz reaction, and an N-acyliminium ion-mediated coupling step. This approach was also successfully applied to a total synthesis of (-)-sedacryptine and one of its epimers.
- Van Der Pijl, Ferdi,Harmel, Robert K.,Richelle, Gaston J. J.,Janssen, Peter,Van Delft, Floris L.,Rutjes, Floris P. J. T.
-
supporting information
p. 2038 - 2041
(2014/05/06)
-
- Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket
-
Herein we describe the design, synthesis, inhibitory potency, and pharmacokinetic properties of a novel class of achiral peptidomimetic HCV NS3 protease inhibitors. The compounds are based on a dipeptidomimetic pyrazinone glycine P3P2 building block in combination with an aromatic acyl sulfonamide in the P1P1′ position. Structure-activity relationship data and molecular modeling support occupancy of the S2 pocket from elongated R6 substituents on the 2(1H)-pyrazinone core and several inhibitors with improved inhibitory potency down to Ki = 0.11 μM were identified. A major goal with the design was to produce inhibitors structurally dissimilar to the di- and tripeptide-based HCV protease inhibitors in advanced stages of development for which cross-resistance might be an issue. Therefore, the retained and improved inhibitory potency against the drug-resistant variants A156T, D168V, and R155K further strengthen the potential of this class of inhibitors. A number of the inhibitors were tested in in vitro preclinical profiling assays to evaluate their apparent pharmacokinetic properties. The various R6 substituents were found to have a major influence on solubility, metabolic stability, and cell permeability.
- Gising, Johan,Belfrage, Anna Karin,Alogheli, Hiba,Ehrenberg, Angelica,?kerblom, Eva,Svensson, Richard,Artursson, Per,Karlén, Anders,Danielson, U. Helena,Larhed, Mats,Sandstr?m, Anja
-
supporting information
p. 1790 - 1801
(2014/04/03)
-
- Selective reduction of esters to aldehydes under the catalysis of well-defined NHC-iron complexes
-
On a direct course to the aldehyde: Hydrosilylation catalyzed by a well-defined N-heterocyclic-carbene-iron complex under UV irradiation enabled the selective reduction of esters to aldehydes (see scheme; Bn=benzyl, Mes=mesityl). The low catalyst loading and very mild reaction conditions make this chemoselective transformation a promising alternative to the reduction of esters with diisobutylaluminum hydride. Copyright
- Li, Haoquan,Misal Castro, Luis C.,Zheng, Jianxia,Roisnel, Thierry,Dorcet, Vincent,Sortais, Jean-Baptiste,Darcel, Christophe
-
supporting information
p. 8045 - 8049
(2013/08/23)
-
- FeCl3?6H2O-catalyzed alkenylation of indoles with aldehydes
-
FeCl3?6H2O-catalyzed efficient C3-alkenylation of indoles was realized through the condensation of aldehydes and indole derivatives in the presence of 2 equiv of ethanol at ambient temperature, forming 3- vinylindoles in up to 93% yields. Ethanol promoted formation of the desired products. An obvious solvent effect was observed, and bisindoles were identified as the reaction intermediates.
- Yang, Qin,Wang, Liandi,Guo, Tenglong,Yu, Zhengkun
-
p. 8355 - 8361
(2013/01/15)
-
- Selective switchable iron-catalyzed hydrosilylation of carboxylic acids
-
Selective reduction of carboxylic acids either to aldehydes or alcohols is achieved using a one pot procedure based on iron-catalyzed hydrosilylations. Using phenylsilane and (COD)Fe(CO)3 catalyst under UV-irradiation at rt, alcohols were obtained specifically in good yields, whereas aldehydes were selectively obtained using TMDS and (t-PBO)Fe(CO)3 catalyst under thermal activation.
- Misal Castro, Luis C.,Li, Haoquan,Sortais, Jean-Baptiste,Darcel, Christophe
-
supporting information
p. 10514 - 10516,3
(2020/09/02)
-
- Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts
-
Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.
- Chernyak, Natalia,Buchwald, Stephen L.
-
supporting information; experimental part
p. 12466 - 12469
(2012/09/05)
-
- The catalytic potential of Coptis japonica NCS2 revealed - Development and utilisation of a fluorescamine-based assay ETI
-
The versatility and potential of a norcoclaurine synthase (NCS) from Coptis japonica NCS2 has been investigated, together with the development and application of a novel fluorescence-based high-throughput assay using nearly forty amines/aldehydes. The stereocontrol exerted by CjNCS2 on selected non-natural substrates has been determined, where the tetrahydroisoquinolines (THIAs) were formed as the (1S)-isomer in >95% ee, as observed with the natural product norcoclaurine. Docking calculations involving THIA mechanism intermediates, utilising the reported Thalictrum flavum NCS X-ray crystallographic structure, were carried out and combined with the CjNCS2 screening results to further understand the mode of action of NCS. These findings suggested that in addition to the key active-site residues K122 and E110, D141 is also mechanistically essential for the enzymatic transformation. The exceptional tolerance of NCS towards aldehyde substrates is furthermore supported by our proposed mechanism in which the aldehydes protrude out of the enzymatic pocket. Copyright
- Pesnot, Thomas,Gershater, Markus C.,Ward, John M.,Hailes, Helen C.
-
supporting information
p. 2997 - 3008
(2013/01/15)
-
- Microwave-assisted synthesis of 5-substituted 2-aminothiophenes starting from arylacetaldehydes
-
An easy three-step pathway for the synthesis of arylacet-aldehydes from the corresponding carboxylic acids in very high yields is described. Their use as precursors of 5-substituted-2-aminothiophenes is illustrated via a microwave-assisted Gewald reaction. This method allows obtaining the expected compounds in a shorter time and with better yields and purities than the classical procedures. Georg Thieme Verlag Stuttgart - New York.
- Revelant, Germain,Dunand, Sandrine,Hesse, Stephanie,Kirsch, Gilbert
-
p. 2935 - 2940
(2011/11/01)
-
- 5-AMINO- 4-HYDROXYPENTOYL AMIDES
-
HIV inhibitors of formula (I) wherein R1 is halo, C1-4alkoxy, trifluoromethoxy; R2 is a group of formula (A); R3 is a group of formula (B); R4 is a group of formula (C); n is 0 or 1; A is CH or N; R5 and R6 are hydrogen, C1-4alkyl, halo; R7 and R8 are C1-4alkyl or C1-4alkoxyC1-4alkyl; R9 is C1-4alkyl, cyclopropyl, trifluoromethyl, C1-4alkoxy, or dimethylamino; R10 is hydrogen, C1-4alkyl, cyclopropyl, trifluoromethyl, C1-4alkoxy, or dimethylamino; pharmaceutically acceptable addition salts and solvates thereof; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds.
- -
-
Page/Page column 25
(2011/06/26)
-
- Small Molecule Inhibitors of Toll-Like Receptor 9
-
Small molecule compounds and compositions containing said compounds useful for inhibiting signaling by certain Toll-like receptors (TLRs), particularly TLR9, are provided. The compounds and compositions can be used to inhibit immune responses, including unwanted immune responses in particular. Compounds, compositions, and methods are provided to treat a variety of conditions involving unwanted immune responses, including for example autoimmune disease, inflammation, transplant rejection, and sepsis.
- -
-
Page/Page column 59
(2010/07/04)
-
- Halonium ion-assisted deiodination of styrene-based vicinal iodohydrins followed by rearrangement through phenyl migration
-
(Chemical Equation Presented) Acid activation of bromate/bromide couple at 0-10°C was found to trigger the deiodination of styrene-based vicinal iodohydrins. Violet coloration of the organic layer was ascribed to formation of IBr. Deiodination was followed by phenyl migration and deprotonation leading to formation of phenyl acetone and 2-phenylpropanal in good yields from 1-iodo-2-phenylpropan-2-ol and 2-iodo-1-phenylpropan-1-ol, respectively. Phenyl acetaldehyde-which was obtained in 92% GC yield from styrene iodohydrin-was also presumably formed in analogous manner. NBS and HOCl too were effective for transformation of styrene iodohydrin into phenyl acetaldehyde. 2009 American Chemical Society.
- Agrawal, Manoj K.,Ghosh, Pushpito K.
-
experimental part
p. 7947 - 7950
(2010/01/16)
-
- The scope of the Heck arylation of enol ethers with arenediazonium salts: a new approach to the synthesis of flavonoids
-
The scope of the Heck arylation of cyclic and acyclic enol ethers with arenediazonium salts was evaluated. Arylation of 2,3-dihydrofuran yielded 2-aryl-2,5-dihydrofurans as the major adducts (>99:1) except when using n-Bu4NHSO4 as ad
- Machado, Angelo H.L.,de Sousa, Marcio A.,Patto, Daniela C.S.,Azevedo, Luiz F.S.,Bombonato, Fernanda I.,Correia, Carlos Roque D.
-
supporting information; experimental part
p. 1222 - 1225
(2009/05/31)
-
- Ruthenium porphyrin-catalyzed aerobic oxidation of terminal aryl alkenes to aldehydes by a tandem epoxidation-isomerization pathway
-
(Figure Presented) Catalytic oxidation of 1-alkenes to aldehydes by an epoxidation-isomerization pathway with air or dioxygen as terminal oxidant has been realized for bulky ruthenium(VI) porphyrin catalysts. For the new, recyclable catalyst [RuVI(tmttp)O2], product yields of up to 99% and total turnover numbers of up to 1144 were obtained.
- Jiang, Gaoxi,Chen, Jian,Thu, Hung-Yat,Huang, Jie-Sheng,Zhu, Nianyong,Che, Chi-Ming
-
supporting information; experimental part
p. 6638 - 6642
(2009/03/12)
-
- Mild oxidation of styrene and its derivatives with ionic manganese porphyrin immobilized in the similarly structured ionic liquid
-
Without the auxiliary involvement of axial ligands and organic solvents, the ionic manganese porphyrin 1c immobilized in [BPy][BF4] efficiently catalyzed the oxidation of styrene and its derivatives under mild conditions, affording high activity/oxide selectivity and good stability even after 5 recycling uses. Copyright
- Liu, Ye,Zhang, Hong-Jiao,Cai, Yue-Qin,Wu, Hai-Hong,Liu, Xiu-Li,Lu, Yong
-
p. 848 - 849
(2008/02/12)
-
- Multypodal tethers for high-density attachment of redox-active moieties to substrates
-
This invention provides redox-active molecules attached to polypodal (e.g., bipodal, tripodal, quadrapodal, pentapodal, etc.) tethers that can be used for attachment of the redox-active molecules to a substrate (e.g., an electrode). The tethered redox-active molecules are useful for the fabrication of memory devices.
- -
-
-
- NEW DERIVATIVES OF 2-PYRIDIN ACETIC ACID AS COMPOUNDS WITH ANTIPROLIFERATIVE ACTIVITY
-
The present invention refers to new derivatives of 2-pyridin acetic acid usefully employable as antagonists of the action of some growth factors and therefore their use as drugs active in the treatment and/or prevention of pathologies deriving from uncont
- -
-
Page/Page column 24
(2008/06/13)
-
- Diazo reactions with unsaturated compounds: VII. Vinyl p-methylphenyl and vinyl p-nitrophenyl ethers in the Meerwein reaction
-
Vinyl p-methylphenyl ether in aqueous acetone at pH 3-4 in the presence of catalytic amounts of copper(II) chloride reacts with arenediazonium chlorides to form arylacetaldehydes. Vinyl p-nitrophenyl ether under the same conditions fails to react with are
- Naidan,Fesak
-
p. 1419 - 1420
(2007/10/03)
-
- O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
-
Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
- -
-
Page column 71
(2010/11/29)
-
- Mechanistic studies of the oxidation of substituted phenethyl alcohols by N-metallo-N-haloarylsulphonamides: Kinetic isotope studies
-
The oxidation of para-substituted phenethyl alcohols (PEA, 2) by N-metallo-N-haloarylsulphonamides (1) in the presence of dilute HCl to the corresponding phenacetaldehydes (4) is first order with respect to oxidant (1) and [H+] and a fract ional order each in [PEA] and [Cl-]. Addition of the reaction product (3), ionic strength variations and variation of dielectric constant of the medium had no effect on the rate. The oxidation of PhCH2CD2OH (2) exhibited a substantial primary kinetic isotope effect (kH/kD=5.83). The rates correlate satisfactorily with the Hammett free energy relationship. The activation parameters ΔH≠, ΔS≠, ΔG≠ and logA were calculated for the i reaction. The proposed mechanism is consistent with the observed results. Copyright
- Rangappa, Kanchugarakoppal S.
-
p. 684 - 690
(2007/10/03)
-
- Diazo reactions with unsaturated compounds: V.1 reaction of phenyl vinyl ether with arenediazonium chlorides
-
Phenyl vinyl ether reacts with arenediazonium chlorides in aqueous acetone at pH 3-4 in the presence of a catalytic amount of copper(II) chloride to give arylacetaldehydes and small amounts 1-aryl-2-phenoxyethenes. No reaction occurs between the same reactants in the presence of sulfur(IV) oxide. 2000 MAIK "Nauka/Interperiodica".
- Naidan
-
p. 1600 - 1602
(2007/10/03)
-
- Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
-
Compounds of the formula STR1 have retinoid-like or retinoid antagonist-like biological activity.
- -
-
-
- Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
-
Compounds of the formula STR1 having retinoid like biological activity.
- -
-
-
