- A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas
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(Chemical Equation Presented) A one-step synthesis of thiazolo[5,4-b] pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6-nitrothiazo
- Sahasrabudhe, Kiran P.,Estiarte, M. Angels,Tan, Darlene,Zipfel, Sheila,Cox, Matthew,O'Mahony, Donogh J. R.,Edwards, William T.,Duncton, Matthew A. J.
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experimental part
p. 1125 - 1131
(2010/03/01)
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- Thiazolo [4,5-6] pyridine derivatives and anti-ulcerative composition containing same
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Compounds of the general formula (I): STR1 and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH= or --N=, with the proviso that at least one of them is --N=; X represents --NH--, --O-- or --S--; Y represents --(CH2)p -- wherein p is an integer from 0 to 4, --C(CH3)2 --, --CH2 CH=CH--, --CH2 CO--, --CF2 -- or --CH2 COCH2 --; R1 represents a hydrogen atom, a C1-4 alkyl group, a halogen atom or a C1-4 alkoxy group; R2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C1-6 alkyl group, a C1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-membered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR3 R4, --NR3 R4, --OCOR3 or --NHCONHR3 wherein R3 and R4, which may be the same or different, represent a C1-6 alkyl group which may be optionally substituted or a cycloalkyl group, and m and n each represent an integer from 0 to 2.
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