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273-84-7

273-84-7

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273-84-7 Usage

General Description

[1,3]thiazolo[5,4-b]pyridine is a heterocyclic compound with a fused thiazole and pyridine ring structure. It is a nitrogen-containing organic compound with potential applications in pharmaceutical and agrochemical industries. This chemical has been studied for its potential biological activities, including as an antiviral and antibacterial agent. It also has the potential to be used as a building block in organic synthesis for the development of new compounds with desirable properties. Its unique structure and potential biological activities make it an interesting target for further research and development in the field of medicinal chemistry and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 273-84-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,7 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 273-84:
(5*2)+(4*7)+(3*3)+(2*8)+(1*4)=67
67 % 10 = 7
So 273-84-7 is a valid CAS Registry Number.

273-84-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [1,3]Thiazolo[5,4-b]pyridine

1.2 Other means of identification

Product number -
Other names THIAZOLO[5,4-B]PYRIDIN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:273-84-7 SDS

273-84-7Synthetic route

2-Chloro-3-nitropyridine
5470-18-8

2-Chloro-3-nitropyridine

thiocarboxamide
115-08-2

thiocarboxamide

[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
In sulfolane at 135℃; Microwave irradiation;26%
thiazolo[5,4-b]pyridine-2-carboxylic acid
857969-93-8

thiazolo[5,4-b]pyridine-2-carboxylic acid

[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
at 160 - 175℃;
2-methylthiazolo[5,4-b]pyridine
91813-40-0

2-methylthiazolo[5,4-b]pyridine

[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous KMnO4
2: 160 - 175 °C
View Scheme
2-Chloro-3-nitropyridine
5470-18-8

2-Chloro-3-nitropyridine

[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium disulfide
2: zinc-powder; acetic acid anhydride; acetic acid
3: aqueous KMnO4
4: 160 - 175 °C
View Scheme
3,3’-dinitro-2,2’-dipyridinyl disulfide
4282-19-3

3,3’-dinitro-2,2’-dipyridinyl disulfide

[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc-powder; acetic acid anhydride; acetic acid
2: aqueous KMnO4
3: 160 - 175 °C
View Scheme
[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

N-(((E)-2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

N-(((E)-2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

N-((2-chlorophenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402598-55-3

N-((2-chlorophenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions
ConditionsYield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.166667h;
Stage #2: N-(((E)-2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 0.166667h;		15%
[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

2-mercapto-3-amino pyridine
38240-21-0

2-mercapto-3-amino pyridine

Conditions
ConditionsYield
With hydrazine hydrate Ambient temperature;
[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

1-(2-chlorophenyl)-4-iodo-5-methyl-1H-[1,2,3]triazole
864867-07-2

1-(2-chlorophenyl)-4-iodo-5-methyl-1H-[1,2,3]triazole

4-(thiazolo[5,4-b]pyridine-2-yl)-1-(2-chlorophenyl)-5-methyl-1H-[1,2,3]triazole

4-(thiazolo[5,4-b]pyridine-2-yl)-1-(2-chlorophenyl)-5-methyl-1H-[1,2,3]triazole

Conditions
ConditionsYield
With sodium acetate; trans-di-µ-acetatebis[2-(di-o-tolylphosphino)benzyl]dipalladium (II) In N,N-dimethyl-formamide at 140℃; for 8h;
[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

N-((2-(methylsulfanyl)phenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402599-44-3

N-((2-(methylsulfanyl)phenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

N-((2-(methylsulfanyl)phenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402607-94-6

N-((2-(methylsulfanyl)phenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions
ConditionsYield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.25h;
Stage #2: N-((2-(methylsulfanyl)phenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 0.166667h;
[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

N-((2-methoxyphenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402599-45-4

N-((2-methoxyphenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

N-((2-methoxyphenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402598-52-0

N-((2-methoxyphenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions
ConditionsYield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.25h;
Stage #2: N-((2-methoxyphenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 0.166667h;
[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

N-((2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402599-46-5

N-((2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

N-((2-chlorophenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402598-55-3

N-((2-chlorophenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions
ConditionsYield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.166667h;
Stage #2: N-((2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 0.166667h;
[1,3]thiazolo[5,4-b]pyridine
273-84-7

[1,3]thiazolo[5,4-b]pyridine

N-((3-methoxy-2-pyridinyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402599-47-6

N-((3-methoxy-2-pyridinyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

N-((3-methoxy-2-pyridinyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide
1402598-58-6

N-((3-methoxy-2-pyridinyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions
ConditionsYield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.25h;
Stage #2: N-((3-methoxy-2-pyridinyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 6h;

273-84-7Relevant articles and documents

A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas

Sahasrabudhe, Kiran P.,Estiarte, M. Angels,Tan, Darlene,Zipfel, Sheila,Cox, Matthew,O'Mahony, Donogh J. R.,Edwards, William T.,Duncton, Matthew A. J.

experimental part, p. 1125 - 1131 (2010/03/01)

(Chemical Equation Presented) A one-step synthesis of thiazolo[5,4-b] pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6-nitrothiazo

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