Process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol
A novel process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol of the general formula: STR1 in which R is a C1 -C8 -alkyl group. In the process, cyanamide is reacted with the appropriate alcohol in the presence of hydrogen chloride to give the corresponding alkoxyisourea hydrochloride, which is then converted with ethyl trifluoroacetoacetate in the presence of an alkali metal hydroxide, which is in water, to the end product of the formula I.
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(2008/06/13)
N and O-isopropyl isomers of barbital and phenobarbital: Physicochemical and pharmacological properties
Univocal synthesis of O and N isopropylated derivatives of barbital and phenobarbital is proposed. Properties of those compounds in solution (pka and lipophilicity) show important differences. However the phenobarbital derivatives keep the anticonvulsant
Menez,Bourin,Colombel,et al.
p. 521 - 529
(2007/10/02)
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