28811-41-8Relevant articles and documents
Process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol
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, (2008/06/13)
A novel process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol of the general formula: STR1 in which R is a C1 -C8 -alkyl group. In the process, cyanamide is reacted with the appropriate alcohol in the presence of hydrogen chloride to give the corresponding alkoxyisourea hydrochloride, which is then converted with ethyl trifluoroacetoacetate in the presence of an alkali metal hydroxide, which is in water, to the end product of the formula I.