- A zinc Lewis acid surface active agent for the preparation of 5' - substituted tetrazole compounds
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The invention belongs to the field of organic synthetic technology, and specifically relates to a zinc Lewis acid surfactant as catalysts for preparing the 5' - substituted compound four azole class method. The method comprises the following steps: 1) to zinc Lewis acid surfactant Zn (OSO2 Cn H2 N + 1 )2 As the catalyst, R cyanide and sodium azide in water reaction to obtain the 5' - R base four nitrogen zuo compound of zinc salt and by-product NaOSO2 Cn H2 N + 1 ; 2) In the step 1) of the obtained 5 '- R base four nitrogen zuo compound of zinc salt in the acidification is carried out under acidic conditions, to obtain the 5' - R base four nitrogen zuo compounds and by-product zinc bromide; 3) by-product NaOSO2 Cn H2 N + 1 And by-product zinc bromide in the substitution reaction under acidic conditions, to obtain zinc Lewis acid surfactant Zn (OSO2 Cn H2 N + 1 )2 . Method can be used in "one-pot" strategy, the starting material by continuous cyclization reaction, the acidification reaction directly preparation containing the tetrazole compound of the structural unit; the method used in the zinc Lewis acid surfactant can be recovered after the reaction.
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Paragraph 0064-0072
(2018/09/08)
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- One-pot synthesis of 5-alkylsulfanyl-1H-tetrazoles from alkyl halides
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An efficient one-pot method for the synthesis of 5-alkylsulfanyl-1H-tetrazoles, tetrazol-5-ylmethane- and -ethanethiol derivatives was developed.
- Myznikov,Vorona,Artamonova,Zevatskii, Yu. E.
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p. 1313 - 1316
(2017/08/08)
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- Synthesis of thiotetrazoles and arylaminotetrazoles using rutile TiO 2 nanoparticles as a heterogeneous and reusable catalyst
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A novel method is described to prepare rutile TiO2 nanoparticles which are reusable and efficient heterogeneous catalysts for the synthesis of thiotetrazoles and arylaminotetrazoles - compounds widely used in medicinal and coordination chemistry. This procedure has the advantages of good to excellent yields of products, elimination of homogeneous catalysts and toxic and explosive reagents, simple methodology, easy work up and the reusability of the heterogeneous catalyst.
- Maham, Mehdi,Khalaj, Mehdi
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p. 502 - 506
(2014/11/08)
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- Preparation of 5-substituted 1H-tetrazoles from nitriles in water
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The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamides have all been shown to be viable substrates for this reaction.
- Demko, Zachary P.,Sharpless, K. Barry
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p. 7945 - 7950
(2007/10/03)
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- From tetrazoles via hydrazonoyl chlorides to 1,3,4-thiadiazole oligomers
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5-Substituted tetrazoles react rapidly with Appel salt 1 at room temperature to give hydrazonoyl chlorides (14) in high yield. 5-Aminotetrazole reacts further to give an extended bis-imine (6) which, with triphenylphosphine at room temperature, rapidly gives 1,3,4-thiadiazoles 15 and 17. The mono-imines 14 react similarly to give simpler thiadiazoles 18 in high yield. By repetition of the tetrazole formation and Appel salt-triphenylphosphine sequence, these 2-cyanothiadiazoles 18 are converted in high yield into thiadiazole dimers and trimers 21, n = 1 and 2. These reactions are explained mechanistically. (C) 2000 Elsevier Science Ltd.
- Le,Rees,Sivadasan
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p. 9407 - 9411
(2007/10/03)
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