- (Salen)Mn(III)-catalyzed chemoselective acylazidation of olefins
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We describe a (salen)Mn(iii)-catalyzed three-component reaction of aldehydes, olefins, and sodium azide for the installation of two useful groups (C═O and N3) into the double bond. Traditionally, (salen)Mn(iii) in conjunction with iodosobenzene is a classical catalysis system for epoxidation of olefins. Owing to the highly competitive oxygenation approaches, it is a true challenge to establish a distinct strategy for the exploration of new olefin transformations based on this (salen)Mn(iii) catalysis system. Herein, the key to this (salen)Mn(iii)-catalyzed acylazidation of olefins was the rational application of the distinct reactivity of oxomanganese(v) species which is capable of abstracting a hydrogen atom from a substrate C-H bond. This chemoselective reaction occurred in a precisely designed reaction sequence and tolerates complex molecular structures.
- Zhang, Liang,Liu, Shuya,Zhao, Zhiguo,Su, Hongmei,Hao, Jingcheng,Wang, Yao
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Read Online
- Synergistic effect of additives on cyclopropanation of olefins
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An efficient cyclopropanation of olefins with Zn(CH2I) 2, a catalytic amount of CCl3CO2H, and 1,2-dimethoxyethane at room temperature is described. A wide variety of olefins, including acid-sensitive substrates,
- Cheng, Donghao,Huang, Deshun,Shi, Yian
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supporting information
p. 5588 - 5591
(2013/09/12)
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- HEPATITIS C VIRUS INHIBITORS
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This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds
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Page/Page column 108
(2012/04/10)
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- HEPATITIS C VIRUS INHIBITORS
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This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
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Page/Page column 106
(2010/11/03)
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- ASYMMETRIC CYCLOPROPANATION
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The present invention provides a method for asymmetric cyclopropanation of olefins comprising admixing an olefin, an enantiomerically enriched amino acid derivative, and a (halomethylene)zinc compound under conditions sufficient to produce an enantiomeric
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Page/Page column 13-16
(2010/02/11)
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- Redox-photosensitized aminations of 1,2-benzo-1,3-cycloalkadienes, arylcyclopropanes, and quadricyclane with ammonia
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1,2,4-Triphenylbenzene and 2,2′-methylenedioxy-1,1′ -binaphthalene successfully photosensitized the aminations of 1,2-benzo-1,3-cycloalkadienes, arylcyclopropanes, and quadricyclane with ammonia and primary amines in the presence of m- or p-dicyanobenzene, which gave the 4-amino-1,2-benzocycloalkenes, 3-amino-1-arylpropanes, and 7-amino-5-(p-cyanophenyl)bicyclo[2.2.1]hept-2-ene, respectively. A key pathway for the photosensitized amination is the hole transfer from the cation radicals of the sensitizers that were generated by photoinduced electron transfer to the electron acceptors to the substrates. Therefore, it was found that the relationships in oxidation potentials between the sensitizers and the substrates and the positive charge distribution of the cation radicals of the substrates were important factors for the efficient amination.
- Yasuda, Masahide,Kojima, Ryuji,Tsutsui, Hiroshi,Utsunomiya, Daigo,Ishii, Kazuaki,Jinnouchi, Koutaro,Shiragami, Tsutomu
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p. 7618 - 7624
(2007/10/03)
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- Ruthenium(II) porphyrin catalyzed cyclopropanation of alkenes with tosylhydrazones
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The diastereoselective ruthenium(II) porphyrin catalyzed cyclopropanation of a variety of alkenes with aryl diazomethanes generated in situ from stable tosylhydrazone derivatives, was achieved in good to excellent yields (up to 92%) and product turnovers.
- Zhang, Jun-Long,Hong Chan, Philip Wai,Che, Chi-Ming
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p. 8733 - 8737
(2007/10/03)
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- Ruthenium(I)-catalyzed cyclopropanation reactions with (trimethylsilyl)diazomethane and aryldiazomethanes
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The polymeric ruthenium(I) complex [Ru2(CO)4(μ-OAc)2]n is a suitable catalyst for the cyclopropanation of mono-, 1,1- as well as 1,2-disubstituted, and trisubstituted alkenes with (trimethylsilyl)diazomethane, phenyl-diazomethane, and (4-cyanophenyl)diazomethane. Trisubstituted alkenes are cyclopropanated with a remarkable degree of syn-selectivity.
- Maas, Gerhard,Seitz, Jürgen
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p. 6137 - 6140
(2007/10/03)
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- The nickel and palladium catalyzed stereoselective cross coupling of cyclopropyl nucleophiles with aryl halides
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The reaction of 2-phenylcyclopropylzinc chloride with some substituted (het)aryl halides gave the corresponding coupling products with good yields and stereoselectivities under the influence of a catalytic amount of Pd(PPh3)4. Other Ni- and Pd-catalysts were less efficient. Alkyl-substituted cyclopropyl nucleophiles gave lower yields.
- De Lang,Brandsma
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p. 225 - 232
(2007/10/03)
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- Diphenylcyclopropyl analogs
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Diphenylcyclopropyl analogs in which one or more of the phenyl rings includes alkoxy substituents including a dialkylaminoalkoxy group, an unsubstituted piperazine alkoxy group, a substituted piperazine alkoxy group, an unsubstituted piperidine alkoxy group, and a substituted piperidine alkoxy group, and which may have one or two alkyl groups bonded to the cyclopropane. The compounds are useful as antiestrogens and anti-tumor agents.
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- Diphenylcyclopropyl analogs
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Diphenylcyclopropyl analogs in which one or more of the phenyl rings includes alkoxy substituents including a dialkylaminoalkoxy group, an unsubstituted piperazine alkoxy group, a substituted piperazine alkoxy group, an unsubstituted piperidine alkoxy group, and a substituted piperidine alkoxy group, and which may have one or two alkyl groups bonded to the cyclopropane. The compounds are useful as antiestrogens and anti-tumor agents.
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- Diphenylcyclopropyl analogs
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Diphenylcyclopropyl analogs in which one or more of the phenyl rings includes alkoxy substituents including a dialkylaminoalkoxy group, an unsubstituted piperazine alkoxy group, a substituted piperazine alkoxy group, an unsubstituted piperidine alkoxy group, and a substituted piperidine alkoxy group, and which may have one or two alkyl groups bonded to the cyclopropane. The compounds are useful as antiestrogens and anti-tumor agents.
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- Lamp versus laser photolysis of 1,3-dichloro-1,3-diphenylpropane in cyclohexane. Direct observation of 1,3-diphenylpropenyl radical
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Laser photolysis of the title compound leads to two-photon processes indicating the involvement of the 1,3-diphenylpropanediyl biradical (12) and the 1,3-diphenylallyl radical (10).
- Perez-Prieto, Julia,Miranda, Miguel Angel,Font-Sanchis, Enrique,Konya, Klara,Scaiano
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p. 4923 - 4926
(2007/10/03)
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- Zinc-promoted reactions. 6. The reduction of diphenylcyclopropenone in acidic media
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The reduction of diphenylcyclopropenone with zinc was investigated under a variety of conditions. The product distribution can be explained in terms of a general mechanism for zinc-promoted reductions.
- Di Vona, Maria Luisa,Rosnati, Vittorio
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p. 10925 - 10930
(2007/10/02)
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- Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fertility agents
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Anti-estrogenic cyclopropyl analogs such as 1,1-dichlorocis-2,3-diphenylcyclopropane, when administered to a subject function as anti-tumor agents to prevent the development of estrogen-dependent tumors in the subject and substantially arrest the growth and metastatic involvement of existing estrogen-dependent tumors in the subject. Further, the anti-estrogenic cyclopropyl analogs may be used as anti-estrogenic agents and as fertility agents in the treatment of female infertility. The cyclopropyl analogs useful as anti-tumor, anti-estrogenic and female fertility agents have the general structure wherein: X is a halogen or hydrogen atom; R1 is a hydrogen atom, an alkyl group containing from 1 to about 3 carbon atoms, a monocyclic group, a hydroxy substituted monocyclic group, an alkoxy substituted monocyclic group in which the alkyl substituent contains from 1 to about 3 carbon atoms or an acetoxy substituted monocyclic group; R2 is a hydrogen atom, an acetate group, a hydroxyl group, an alkoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms, a beta-dialkylaminoethoxy group wherein the alkyl substituent contains from 1 to about 6 carbon atoms, a beta-monoaminoheterocycloethoxy group, or pharmaceutically acceptable salts thereof; R3 is a hydrogen atom, an acetate group, a hydroxyl group, or an alkoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms; R4 is a hydrogen atom, or an alkyl group containing from 1 to about 3 carbon atoms; and the wavy lines ( ) in the structure indicate that the anti-tumor agent can be the cis- or trans-isomers.
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- Cyclopropyl analogs as estrogenic and anti-fertility agents
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Estrogenic cyclopropyl analogs, when administered to a female subject, function as anti-fertility agents to prevent pregnancy in the subject. Further, the estrogenic cyclopropyl analogs may be used as estrogenic agents to produce an estrogenic response in a female subject. The estrogenic cyclopropyl analogs useful as estrogenic agents have the general structure: STR1 wherein: X is a halogen or hydrogen atom: R1 is a hydrogen atom, an alkyl group containing from 1 to about 3 carbon atoms, a monocyclic group, a hydroxy substituted monocyclic group, or an alkoxy substituted monocyclic group in which the alkyl substitutent contains from 1 to about 3 carbon atoms; R2 is a hydrogen atom, an acetate group, a hydroxyl group, an alkoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms, a beta-dialkylaminoethoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms, a beta-monoaminoheterocycloethoxy group, or pharmaceutically acceptable salts thereof; R3 is a hydrogen atom, or an alkyl group containing from 1 to about 3 carbon atoms; R4 is a hydrogen atom, an acetate group, a hydroxyl group, or an alkoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms.
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- RADICAL HYDROFORMYLATION AND HYDROGENATION OF CYCLOPROPENES WITH HCo(CO)4 AND HMn(CO)5
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The results of a study of the reactions of HCo(CO)4 and HMn(CO)5 with a variety of substituted cyclopropenes are consistent with the formation of intermediate caged radical pairs; recombination in the cage of the radical pair leads to hydroformylation, an
- Nalesnik, Theodore E.,Freudenberger, John H,,Orchin, Milton
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