- Thermophysical study of several barbituric acid derivatives by differential scanning calorimetry (DSC)
-
The present study reports a differential scanning calorimetry (DSC) study of the barbituric acid derivatives: 1,3-dimethylbarbituric acid [CAS 769-42-6], 5,5-dimethylbarbituric acid [CAS 24448-94-0], 1,3-diethylbarbituric acid [CAS 32479-73-5], 1,3,5-trimethylbarbituric acid [CAS 7358-61-4], 1,5,5-trimethylbarbituric acid [CAS 702-47-6], and tetramethylbarbituric acid [CAS 13566-66-0] in the temperature interval from T = 268 K to their respective melting temperatures. Temperatures, enthalpies and entropies of fusion, and the heat capacities of the solid compounds as a function of temperature are reported.
- Temprado, Manuel,Roux, Maria Victoria,Ros, Francisco,Notario, Rafael,Segura, Marta,Chickos, James S.
-
-
Read Online
- Compound with aggregation-induced emission property, and application thereof in field of surgical navigation
-
The invention belongs to the technical field of synthesis of compounds with aggregation-induced emission properties, and relates to a compound with an aggregation-induced emission property, and application thereof. The compound has the beneficial effects that 1, a new thought of surgical navigation is provided; 2, materials are easy to obtain, cost is low, and preparation is easy; 3, the biotoxicity is low; and 4, the luminescent wavelength is long, the interference of background fluorescence is small, and the tissue penetrability is strong.
- -
-
Paragraph 0043-0045; 0049
(2021/07/14)
-
- Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding
-
Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.
- Thinnes, Cyrille C.,Lohans, Christopher T.,Abboud, Martine I.,Yeh, Tzu-Lan,Tumber, Anthony,Nowak, Rados?aw P.,Attwood, Martin,Cockman, Matthew E.,Oppermann, Udo,Loenarz, Christoph,Schofield, Christopher J.
-
supporting information
p. 2019 - 2024
(2019/01/11)
-
- Reaction of 1,3-Dialkylbarbituric acids with aliphatic amines
-
On heating triethylammonium 1,3-dimethylbarbiturate, 1,3-dimethylthiobarbiturate, and 1,3-diphenylbarbiturate occurs dealkylation of triethylamine to afford in high yields the corresponding 5-ethyl substituted barbituric acids. The cleavage of alkyl groups happened also efficiently with tributyl, tribenzyl, and dimethylbenzylammonium salts, and less efficiently with trimethylammonium and diethylammonium salts. These reactions are characteristic only of 1.3-disubstituted barbituric acids; the barbituric acid and its 1-alkyl derivatives under these conditions suffer degradation.
- Krasnov
-
p. 280 - 284
(2007/10/03)
-
- A facile entry to fused pyrimidines: Preparation of pyrimido[4,5-b]quinoline and pyrido[2,3-d:6,5-d']dipyrimidine derivatives
-
A number of pyrimido[4,5-b]quinolines 3 and pyrido[2,3-d:6,5-d']-dipyrimidines have been prepared by reaction of N,N'-disubstituted barbituric acids with the iminophosphorane derived from o-azidobenzaldehyde or 6-amino-5-formyl-1,3-dimethyluracil.
- Molina,Vilaplana,Pastor
-
p. 827 - 829
(2007/10/02)
-