32479-73-5

Basic information

• Product Name: 1,3-DIETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
• Synonyms: 1,3-DIETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE;1,3-diethylbarbituric acid
• CAS NO: 32479-73-5
• Molecular Formula: C₈H₁₂N₂O₃
• Molecular Weight: 184.19
• EINECS: 251-064-3
• Mol File: 32479-73-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 262.9°Cat760mmHg
• Flash Point: 107.4°C
• Appearance: /
• Density: 1.202g/cm³
• Vapor Pressure: 0.0106mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: 1,3-DIETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE(32479-73-5)
• EPA Substance Registry System: 1,3-DIETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE(32479-73-5)

Safety Data

• Hazardous Substances Data: 32479-73-5(Hazardous Substances Data)

Usage

Uses

1,3-Diethylbarbituric Acid can be used as reactant/reagent in green preparation of spiropyran derivatives via three-component cyclization of indantrione with active methylene compounds and cyclic diketones in the presence of compact fluorescent lamp.

InChI:InChI=1/C8H12N2O3/c1-3-9-6(11)5-7(12)10(4-2)8(9)13/h3-5H2,1-2H3

Upstream product

• 102-09-0 bis(phenyl) carbonate 
• 63884-60-6 N,N'-bis-ethoxycarbonyl-2,2-diethyl-malonic acid diamide 
• 141-82-2 malonic acid 
• 1663-67-8 malonoyl dichloride 
• 7664-93-9 sulfuric acid 
• 623-76-7 N,N'-diethylurea 
• 693-29-8 N,N'-diethylcarbodiimide 
• 108-19-0 BIURET 
• 54505-72-5 diethylmalonyl chloride 
• 57-13-6 urea 
• 96-31-1 N,N'-Dimethylurea 

Downstream Products

• 115725-78-5 1,3-diethyl-5-[(1,3,3-trimethyl-indolin-2-yliden)-ethylidene]-barbituric acid 
• 86872-79-9 1,3-diethyl-5-(4-dimethylamino-benzylidene)-barbituric acid 
• 37042-04-9 1,3-diethyl-5-(4-oxo-2-phenyl-4H-chromen-3-ylmethylene)-pyrimidine-2,4,6-trione 
• 110-62-3 pentanal 
• 65150-41-6 6-chloro-1,3-diethyluracil 
• 633278-36-1 N,N'-diethyl-1-[5-[2-[4-[N-ethyl-N-(2-hydroxyethyl)amino]phenyl]ethenyl]-2-thienylmethylidene]-2,4,6-(1H,3H,5H)pyrimidinetrione 
• 1248591-27-6 C₂₄H₂₇N₅O₅ 
• 1248591-29-8 C₂₅H₂₉N₅O₅ 
• 1251930-83-2 5-(4-chlorophenyl)-1,3-diethyl-2-thioxo-2,3,8,9-tetrahydro-1H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione 
• 1251930-80-9 5-(4-chlorophenyl)-1,3-diethyl-8,8-dimethyl-2-thioxo-2,3,8,9-tetrahydro-1H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione 
• 1251930-84-3 1,3-diethyl-5-(4-nitrophenyl)-2-thioxo-2,3,8,9-tetrahydro-1H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione 
• 1251930-85-4 1,3-diethyl-8,8-dimethyl-5-(3-nitrophenyl)-2-thioxo-2,3,8,9-tetrahydro-1H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione 
• 1251930-81-0 1,3-diethyl-8,8-dimethyl-5-(4-nitrophenyl)-2-thioxo-2,3,8,9-tetrahydro-1H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione 
• 1251930-78-5 1,3-diethyl-8,8-dimethyl-5-phenyl-2-thioxo-2,3,8,9-tetrahydro-1H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione 

Relevant articles and documents

Thermophysical study of several barbituric acid derivatives by differential scanning calorimetry (DSC)

The present study reports a differential scanning calorimetry (DSC) study of the barbituric acid derivatives: 1,3-dimethylbarbituric acid [CAS 769-42-6], 5,5-dimethylbarbituric acid [CAS 24448-94-0], 1,3-diethylbarbituric acid [CAS 32479-73-5], 1,3,5-trimethylbarbituric acid [CAS 7358-61-4], 1,5,5-trimethylbarbituric acid [CAS 702-47-6], and tetramethylbarbituric acid [CAS 13566-66-0] in the temperature interval from T = 268 K to their respective melting temperatures. Temperatures, enthalpies and entropies of fusion, and the heat capacities of the solid compounds as a function of temperature are reported.

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.

A facile entry to fused pyrimidines: Preparation of pyrimido[4,5-b]quinoline and pyrido[2,3-d:6,5-d']dipyrimidine derivatives

A number of pyrimido[4,5-b]quinolines 3 and pyrido[2,3-d:6,5-d']-dipyrimidines have been prepared by reaction of N,N'-disubstituted barbituric acids with the iminophosphorane derived from o-azidobenzaldehyde or 6-amino-5-formyl-1,3-dimethyluracil.