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32949-40-9

Articles about 32949-40-9Total 3 be found

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DPP4 INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF
The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.
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Page/Page column 8-9

(2008/06/13)

Synthesis of Bitter Peptides Composed of Aspartic Acid and Glutamic acid
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Ohyama, Satoshi,Ishibashi, Norio,Tamura, Masahiro,Nishizaki, Hiroshi,Okai, Hideo
p. 871 - 872
(2007/10/02)

Peptide synthesis in aqueous solution. I. Application of p-dialkyl-sulfoniophenols as a water-soluble coupling reagent
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Kouge,Koizumi,Okai,Kato
p. 2409 - 2418
(2007/10/02)

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Chemical Properties

Boiling Point: 461.0±45.0 °C(Predicted)
Density: 1.272±0.06 g/cm3(Predicted)
Storage Temp.:-15°C
PKA: 2.93±0.10(Predicted)
PSA: 129.72000
LogP: 0.49510

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