32949-40-9

Basic information

• Product Name: H-LEU-ASP-OH
• Synonyms: H-LEU-ASP-OH;L-LEUCYL-L-ASPARTIC ACID;leu-asp;Leu-Asp-OH;L-Leu-L-Asp-OH;N-L-Leucyl-L-aspartic acid
• CAS NO: 32949-40-9
• Molecular Formula: C10H18N2O5
• Molecular Weight: 246.26
• Mol File: 32949-40-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 461.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.272±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 2.93±0.10(Predicted)
• CAS DataBase Reference: H-LEU-ASP-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-LEU-ASP-OH(32949-40-9)
• EPA Substance Registry System: H-LEU-ASP-OH(32949-40-9)

Safety Data

• Hazardous Substances Data: 32949-40-9(Hazardous Substances Data)

Usage

General Description

H-LEU-ASP-OH is a chemical compound consisting of the amino acid leucine, the amino acid aspartic acid, and a hydroxyl group. Leucine is a branched-chain amino acid that is important for protein synthesis and muscle growth. Aspartic acid is a non-essential amino acid that plays a role in the urea cycle and the citric acid cycle. The hydroxyl group is a functional group that can participate in hydrogen bonding and chemical reactions. H-LEU-ASP-OH is often used in biochemical and pharmaceutical research as a building block for peptide synthesis and as a potential therapeutic agent for various medical conditions.

Upstream product

• 28659-88-3 (R)-2-Bromo-4-methyl-pentanoyl chloride 
• 28659-88-3 2-bromo-4-methylpentanoyl chloride 
• 2018-66-8 Z-Leu-OH 
• 3350-19-4 (tert-butoxycarbonyl)-L-leucine p-nitrobenzylester 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 3392-09-4 Boc-Leu-ONSu 

Downstream Products

• 61-90-5 L-leucine 
• 56-84-8 L-Aspartic acid 

Relevant articles and documents

DPP4 INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.

Peptide synthesis in aqueous solution. I. Application of p-dialkyl-sulfoniophenols as a water-soluble coupling reagent

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