Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors
The polymer-assisted solution phase synthesis (PASP) of an array of histone deacetylase (HDAc) inhibitors is described. HDAc inhibitors have considerable potential as new anti-proliferative agents. Selected compounds were shown to inhibit both human endothelial cell proliferation, and the formation of tubules (neovascularisation) in an in vitro model of angiogenesis.
Bapna, Akanksha,Vickerstaffe, Emma,Warrington, Brian H.,Ladlow, Mark,Fan, Tai-Ping D.,Ley, Steven V.
p. 611 - 620
(2007/10/03)
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