333434-63-2Relevant articles and documents
Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors
Bapna, Akanksha,Vickerstaffe, Emma,Warrington, Brian H.,Ladlow, Mark,Fan, Tai-Ping D.,Ley, Steven V.
, p. 611 - 620 (2007/10/03)
The polymer-assisted solution phase synthesis (PASP) of an array of histone deacetylase (HDAc) inhibitors is described. HDAc inhibitors have considerable potential as new anti-proliferative agents. Selected compounds were shown to inhibit both human endothelial cell proliferation, and the formation of tubules (neovascularisation) in an in vitro model of angiogenesis.