- Rapid and straightforward transesterification of sulfonyl carbamates
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A fast and convenient method for the alkoxy exchange of sulfonyl carbamates by simply heating in a chosen alkyl alcohol is described. No catalysts or additives are required. Microwave heating at 100-120 °C for 20-60 min resulted in good to excellent yields (53-93%) of alkyl (arylsulfonyl)carbamates where the alkyl part originates from the alcohol solvent. The developed protocol was applied to the synthesis of an angiotensin II type 2 receptor (AT2R) ligand.
- Isaksson, Rebecka,Kumpi?a, Ilze,Larhed, Mats,Wannberg, Johan
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supporting information
p. 1476 - 1478
(2016/03/12)
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- A catalytic, Bronsted base strategy for intermolecular allylic C-H amination
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A Bronsted base activation mode for oxidative, Pd(II)/sulfoxide- catalyzed, intermolecular C-H allylic amination is reported. N,N-diisopropylethylamine was found to promote amination of unactivated terminal olefins, forming the corresponding linear allylic amine products with high levels of stereo-, regio-, and chemoselectivity. The predictable and high selectivity of this C-H oxidation method enables latestage incorporation of nitrogen into advanced synthetic intermediates and natural products.
- Reed, Sean A.,Mazzotti, Anthony R.,White, M. Christina
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supporting information; experimental part
p. 11701 - 11706
(2009/12/08)
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