cas 334981-10-1, 1-[[(4-Aminophenyl)methyl]sulfonyl]-pyrrolidine | Articles data ｜lookchem

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334981-10-1

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NAMPT MODULATORS
Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.
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Paragraph 0254; 0255

(2021/08/13)

Preparation method of almotriptan key intermediate 1-(4-amino-phenylmethylsulfonyl)pyrrolidine
The invention discloses a preparation method of an almotriptan key intermediate 1-(4-amino-phenylmethylsulfonyl)pyrrolidine. The main steps comprise: 1) preparing a Vilsmeier reagent by using BTC andDMF, and carrying out a sulfonylation reaction on p-nitr
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(2018/09/12)

AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON
The invention relates to certain aminopyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).
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(2011/05/05)

PREPARATION AND UTILITY OF SUBSTITUTED INDOLES
Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.
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Page/Page column 39

(2008/06/13)

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Chemical Properties

Appearance/Colour :Pale yellow solid
Melting Point: 170-176 °C
Boiling Point: 434.2 °C at 760 mmHg
Flash Point:216.4 °C
Density: 1.31 g/cm³
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
Storage Temp.:Refrigerator
Vapor Pressure: 9.65E-08mmHg at 25°C
Refractive Index: 1.618
PKA: 4.35±0.10(Predicted)
PSA: 71.78000
LogP: 2.79430

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