334981-10-1

Basic information

• Product Name: 1-[[(4-Aminophenyl)methyl]sulfonyl]-pyrrolidine
• Synonyms: 1-[[(4-aminophenyl)methyl]sulfonyl]-pyrrolidine;4-[(1-Pyrrolidinylsulfonyl)methyl]-benzenamine;n-[(4-aminophenyl)-methylsulfonyl]pyryolidine;4-(1-PYRROLIDINYLSULFONYLMETHYL)ANILINE;4-(Pyrrolidino Sulfonyl Methyl) Benzeneamine;N-[(4-Aminophenyl)methylsulfonyl]pyrrolidine;BENZENAMINE,4-[(1-PYRROLIDINYLSULFONYL)METHYL];1-((4-Aminobenzenemethane)sulfonyl)pyrrolidine
• CAS NO: 334981-10-1
• Molecular Formula: C₁₁H₁₆N₂O₂S
• Molecular Weight: 240.32194
• EINECS: 1308068-626-2
• Product Categories: API intermediates;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Intermediate of Almotriptan
• Mol File: 334981-10-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 170-176°C
• Boiling Point: 434.2 °C at 760 mmHg
• Flash Point: 216.4 °C
• Appearance: Pale yellow solid
• Density: 1.31
• Vapor Pressure: 9.65E-08mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 4.35±0.10(Predicted)
• CAS DataBase Reference: 1-[[(4-Aminophenyl)methyl]sulfonyl]-pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[[(4-Aminophenyl)methyl]sulfonyl]-pyrrolidine(334981-10-1)
• EPA Substance Registry System: 1-[[(4-Aminophenyl)methyl]sulfonyl]-pyrrolidine(334981-10-1)

Safety Data

• Hazardous Substances Data: 334981-10-1(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Intermediate in the preparation of Almotriptan.

InChI:InChI=1/C11H16N2O2S/c12-11-5-3-10(4-6-11)9-16(14,15)13-7-1-2-8-13/h3-6H,1-2,7-9,12H2

Upstream product

• 340041-91-0 1-(4-nitrophenylmethylsulfonyl)pyrrolidine 
• 4025-75-6 (4-nitrophenyl)methanesulfonyl chloride 
• 53992-33-9 (4-nitrophenyl)-methanesulfonic acid 

Downstream Products

• 154323-57-6 almotriptan 
• 1364283-51-1 3-methyl-1-(4-((pyrrolidin-1-ylsulfonyl)methyl)phenyl)-5-(thiophen-2-yl)-1H-pyrazole 
• 1364283-57-7 C₂₁H₂₀F₃N₃O₂S 
• 334981-24-7 1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine 
• 334981-25-8 1-{[4-(N-2-butenyltrifluoroacetamido)-3-iodophenyl]methylsulfonyl}pyrrolodine 
• 334981-40-7 1-{[3-iodo-4-(trifluoroacetamido)phenyl]methylsulfonyl}pyrrolidine 
• 334981-11-2 4-((pyrrolidin-1-ylsulfonyl)methyl)phenylhydrazine hydrochloride 
• 916430-51-8 2-iodo-4-((pyrrolidin-1-ylsulfonyl)methyl)aniline 
• 334981-23-6 1-{[3-bromo-4-(trifluoroacetamido)phenyl]methylsulfonyl}pyrrolidine 

Relevant articles and documents

NAMPT MODULATORS

Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.

AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON

The invention relates to certain aminopyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).