- Preparation method of aryl ketone compound
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The invention provides a preparation method of an aryl ketone compound, and belongs to the technical field of compound synthesis. The method comprises the following steps: under the action of a silver catalyst and water, carrying out reaction on aryl alkyne with a structure as shown in a formula 1 in a solvent at 60-120 DEG C for 12-48 hours, and separating and purifying a product after the reaction is finished, so as to obtain the single aryl ketone compound with a structure as shown in a formula I, the raw materials are easy to obtain, the experimental operation is simple, the yield of the prepared single aryl ketone compound is good, and gram-scale experiments can be carried out.
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Paragraph 0041-0049; 0061-0065; 0067
(2022/04/16)
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- Hydrogen borrowing catalysis using 1° and 2° alcohols: Investigation and scope leading to α and β branched products
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The alkylation of a variety of ketones using 1° or 2° alcohols under hydrogen borrowing catalysis is described. Initial research focused on the α-alkylation of cyclopropyl ketones with higher 1° alcohols (i.e. larger than MeOH), leading to the formation of α-branched products. Our search for additional substrates with which to explore this chemistry led us to discover that di-ortho-substituted aryl ketones were also privileged scaffolds, with Ph? (C6Me5) ketones being the optimal choice. Further investigations revealed that this motif was crucial for alkylation with 2° alcohols forming β-branched products, which also provided an opportunity to study diastereoselective and intramolecular hydrogen borrowing processes.
- Frost, James R.,Cheong, Choon Boon,Akhtar, Wasim M.,Caputo, Dimitri F.J.,Christensen, Kirsten E.,Stevenson, Neil G.,Donohoe, Timothy J.
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supporting information
(2021/04/07)
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- Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones
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In this communication we describe a novel strategy for the formation of valuable diaryl and aryl alkyl ketones from acyl hydrazides. A wide variety of ketones are prepared and the mild reaction conditions allow for the use of a range of functionalities, especially in the synthesis of diaryl ketones.
- Akhbar, Ahmed R.,Chudasama, Vijay,Fitzmaurice, Richard J.,Powell, Lyn,Caddick, Stephen
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p. 743 - 746
(2014/01/06)
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- Ir- and Ru-catalyzed sequential reactions: Asymmetric α-alkylative reduction of ketones with alcohols
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(Chemical Equation Presented) The compatibility between [{IrCl(cod)} 2] and ruthenium complex 1 to achieve asymmetric α-alkylative reduction of prochiral ketones with primary alcohols is an essential factor in obtaining optically active alcohols with elongation of the carbon skeleton in good yields with a high enantioselectivity.
- Onodera, Gen,Nishibayashi, Yoshiaki,Uemura, Sakae
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p. 3819 - 3822
(2007/10/03)
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- Palladium-catalyzed synthesis of aryl ketones from boronic acids and carboxylic acids activated in situ by pivalic anhydride
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A new palladium-catalyzed cross-coupling reaction between arylboronic acids and mixed anhydrides, generated in situ from carboxylic acids and pivalic anhydride, is presented. Optimization of the new catalyst and the reaction conditions led to the development of a convenient one-pot ketone synthesis directly from carboxylic and boronic acids in the presence of different (phosphane)palladium complexes in wet THF at 60 °C. Systematic studies were performed to elucidate the reaction mechanism of this transformation. The scope and the limitations of the new process are demonstrated by the synthesis of 33 functionalized ketones. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
- Goossen, Lukas J.,Ghosh, Keya
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p. 3254 - 3267
(2007/10/03)
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- Efficient acylation of toluene and anisole with aliphatic carboxylic acids catalysed by heteropoly salt Cs2.5H0.5PW12O40
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Heteropoly salt Cs2.5H0.5PW12O40 is a highly efficient and reusable solid acid catalyst for the liquid-phase acylation of toluene or anisole with C2 - C12 aliphatic carboxylic acids.
- Kaur, Jaspal,Kozhevnikov, Ivan V.
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p. 2508 - 2509
(2007/10/03)
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- Friedel-Crafts Acylation of Arenes Catalysed by Bromopentacarbonylrhenium(I)
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The intermolecular Friedel-Crafts acylation of aromatic compounds (such as toluene, m-xylene, and anisole) with various acid chlorides proceeds by using a catalytic amount of bromopentacarbonylrhenium(I) to afford aryl ketones.Intramolecular acylation is also catalyzed by the above-mentioned catalyst to give indanone and tetralone derivatives.
- Kusama, Hiroyuki,Narasaka, Koichi
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p. 2379 - 2384
(2007/10/03)
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