- Method for synthesizing carbamazepine
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The invention discloses a method for synthesizing carbamazepine. The method takes iminodibenzyl and chlorobenzene as raw materials and comprises the following steps: introducing triphosgene to obtainacyl chloride, performing bromination with bromine to obtain bromide, performing ammoniation with ammonium hydroxide to obtain a crude product of the carbamazepine, and finally, refining the crude product with ethanol to obtain a finished product of the carbamazepine. The acyl chlorination, bromination and ammoniation adopt chlorobenzene as a reaction solvent to reduce consumption of other solvents; in the acyl chlorination reaction, the triphosgene replaces phosgene to solve the problems of safety and environmental protection in the process; the obtained acyl chloride is not separated and isdirectly subjected to bromination dehydrogenation and ammoniation reaction to lower the operation cost; the yield of each step of the synthesis process is 93% or higher, thereby improving the production efficiency and lowering the production cost; and the synthesis process adopts self-designed novel closed equipment to reduce the consumption of chlorobenzene and ethanol, thereby being suitable forindustrial production.
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Paragraph 0008; 0009; 0010
(2018/12/13)
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- Electrochemical Studies of Carbamazepine
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Electrochemical investigation of carbamazepine (1) are carried out by cyclic voltammetry, differential pulse polarography and coulometry.The compound undergoes a quasi-reversible two-electron reduction process at the 10,11 C=C of the heterocyclic ring.The cathodic shift in the Epc as pH is increased, indicates the involvement of hydrogen ions in the redox process.A plausible EC mechanism is suggested for the pH and scan rate dependent CV profiles.The mechanism is supported by electronic spectroscopy and coulometry.The diffusion coefficients and conformational isomerisation (following-reaction) rate constants are calculated based on Nicholson and Shain method.An analytical technique in differential pulse polarography is developed for the assaying of carbamazepine in various commercial drug formulations.
- Moses, G. S.,Rao, K. M.,Rao, N. Srinivasa,Ramachandraiah, A.
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p. 333 - 338
(2007/10/03)
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