3564-73-6

Basic information

• Product Name: 10,11-DIHYDROCARBAMAZEPINE
• Synonyms: f)azepine-5-carboxamide,10,11-dihydro-5h-dibenz(;10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE;10,11-DIHYDROCARBAMAZEPINE;10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide;10,11-Dihydro5H-dibenzo[b,f]azepine-5-carboxamide;10,11-Dihydrocarbamazepine,99%;5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide;10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide
• CAS NO: 3564-73-6
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.28
• EINECS: 222-649-0
• Product Categories: Amines;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 3564-73-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 205-210 °C(lit.)
• Boiling Point: 394.5°Cat760mmHg
• Flash Point: 192.4°C
• Appearance: /
• Density: 1.232g/cm³
• Vapor Pressure: 1.96E-06mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: Refrigerator
• Solubility: dichloromethane: soluble2.5%, clear, colorless
• PKA: 14.07±0.20(Predicted)
• Water Solubility: Soluble in dichloromethane. Insoluble in water.
• BRN: 196969
• CAS DataBase Reference: 10,11-DIHYDROCARBAMAZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 10,11-DIHYDROCARBAMAZEPINE(3564-73-6)
• EPA Substance Registry System: 10,11-DIHYDROCARBAMAZEPINE(3564-73-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-42/43
• Safety Statements: 22-24/25-45-36/37
• WGK Germany: 3
• RTECS: HN8300000
• Hazardous Substances Data: 3564-73-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 3564-73-6 differently. You can refer to the following data:
1. A dihydro impurity of Carbamazepine (C175840)
2. 10,11-Dihydrocarbamazepine is used as internal standard during simultaneous determination of carbamazepine and its active metabolite in plasma by liquid chromatography. It can be used in chemiluminescence method for determination of carbamazepine.

General Description

10,11-Dihydrocarbamazepine is an impurity present in dibenzazepine drug used in the treatment of epilepsy. Single-crystal structure of new dimer-based polymorph of 10,11-dihydrocarbamazepine has been investigated.

InChI:InChI=1/C15H14N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-8H,9-10H2,(H2,16,18)

Upstream product

• 33948-19-5 10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride 
• 298-46-4 carbamazepin 
• 33948-22-0 5H-dibenz[b,f]azepine-5-carbonylchloride 
• 494-19-9 9,10-dihydrodibenzazepine 

Downstream Products

• 29331-92-8 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide 
• 298-46-4 carbamazepin 
• 28721-07-5 oxcarbazepine 
• 537693-29-1 10,11-dioxo-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide 

Relevant articles and documents

Method for synthesizing carbamazepine

The invention discloses a method for synthesizing carbamazepine. The method takes iminodibenzyl and chlorobenzene as raw materials and comprises the following steps: introducing triphosgene to obtainacyl chloride, performing bromination with bromine to obtain bromide, performing ammoniation with ammonium hydroxide to obtain a crude product of the carbamazepine, and finally, refining the crude product with ethanol to obtain a finished product of the carbamazepine. The acyl chlorination, bromination and ammoniation adopt chlorobenzene as a reaction solvent to reduce consumption of other solvents; in the acyl chlorination reaction, the triphosgene replaces phosgene to solve the problems of safety and environmental protection in the process; the obtained acyl chloride is not separated and isdirectly subjected to bromination dehydrogenation and ammoniation reaction to lower the operation cost; the yield of each step of the synthesis process is 93% or higher, thereby improving the production efficiency and lowering the production cost; and the synthesis process adopts self-designed novel closed equipment to reduce the consumption of chlorobenzene and ethanol, thereby being suitable forindustrial production.

Electrochemical reduction of 5H-dibenz[b,f]azepine derivatives. Part 5: Cathodic behaviour of carbamazepine-ammonium halide addition compounds

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