cas 3663-97-6, AcetaMide, N-[4-(3-chloro-1-oxopropyl)phenyl]- | Articles data ｜lookchem

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3663-97-6

Articles about 3663-97-6Total 2 be found

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Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors
We report the discovery of the pyrimido-diazepine scaffolds as novel adenine mimics. Structure-based design led to the discovery of analogs with potent inhibitory activity against receptor tyrosine kinases, such as KDR, Flt3 and c-Kit. Compound 14 exhibited low nanomolar KDR enzymatic and cellular potencies (IC50 = 9 and 52 nM, respectively).
Gracias, Vijaya,Ji, Zhiqin,Akritopoulou-Zanze, Irini,Abad-Zapatero, Cele,Huth, Jeffrey R.,Song, Danying,Hajduk, Philip J.,Johnson, Eric F.,Glaser, Keith B.,Marcotte, Patrick A.,Pease, Lori,Soni, Nirupama B.,Stewart, Kent D.,Davidsen, Steven K.,Michaelides, Michael R.,Djuric, Stevan W.
p. 2691 - 2695
(2008/12/21)

Chemotherapy of tuberculosis. IX. Synthesis and screening of new thiazolyl thiocarbanilides.
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Kulkarni,Fernandez,Patel,Bellare,Deliwala
p. 852 - 857
(2007/10/04)

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Chemical Properties

Boiling Point: 453.1°C at 760 mmHg
Flash Point:227.8°C
Density: 1.24g/cm³
Vapor Pressure: 2.12E-08mmHg at 25°C
PSA: 46.17000
LogP: 2.52960

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