3663-97-6 Usage
General Description
Acetamide, N-[4-(3-chloro-1-oxopropyl)phenyl]- is a chemical compound with the molecular formula C11H11ClN2O2. It is a derivative of acetamide with a phenyl group attached to the nitrogen atom and a 3-chloropropyl group attached to the phenyl ring. AcetaMide, N-[4-(3-chloro-1-oxopropyl)phenyl]- is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also known to have applications in the field of organic synthesis and as a reagent in chemical reactions. However, it is important to handle this chemical with care, as it may have harmful effects on human health and the environment if not properly managed.
Check Digit Verification of cas no
The CAS Registry Mumber 3663-97-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,6 and 3 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3663-97:
(6*3)+(5*6)+(4*6)+(3*3)+(2*9)+(1*7)=106
106 % 10 = 6
So 3663-97-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H12ClNO2/c1-8(14)13-10-4-2-9(3-5-10)11(15)6-7-12/h2-5H,6-7H2,1H3,(H,13,14)
3663-97-6Relevant articles and documents
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors
Gracias, Vijaya,Ji, Zhiqin,Akritopoulou-Zanze, Irini,Abad-Zapatero, Cele,Huth, Jeffrey R.,Song, Danying,Hajduk, Philip J.,Johnson, Eric F.,Glaser, Keith B.,Marcotte, Patrick A.,Pease, Lori,Soni, Nirupama B.,Stewart, Kent D.,Davidsen, Steven K.,Michaelides, Michael R.,Djuric, Stevan W.
, p. 2691 - 2695 (2008/12/21)
We report the discovery of the pyrimido-diazepine scaffolds as novel adenine mimics. Structure-based design led to the discovery of analogs with potent inhibitory activity against receptor tyrosine kinases, such as KDR, Flt3 and c-Kit. Compound 14 exhibited low nanomolar KDR enzymatic and cellular potencies (IC50 = 9 and 52 nM, respectively).
