Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a 1,2-diarylethylamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of interest are those of the formula wherein each of R1 and R2 is a group independently selected from hydrido, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, hydroxyl, alkoxy, halo, cyano, nitro and mercapto, or wherein R1 and R2 may be taken together to form an oxo group or to form a saturated or partially unsaturated carbocyclic group having three to eight ring carbons; wherein each of Ar1 and Ar2 is a group independently selected from aryl and heteroaryl having one or two heteroatoms selected from N, O and S; and wherein any of the foregoing Ar1 and Ar2 groups having a substitutable position msy be substituted with one or more radicals selected from hydrido, alkyl, cycloalkyl, halo, haloalkyl, alkenyl, alkynyl, hydroxyl, hydroxyalkyl, alkoxy, alkoxyalkyl, amino, cyano, nitro and mercapto; wherein X is selected from CH, CH2, NH, O and S, to form a ring having five to eight members provided that such ring is saturated or contains one double bond or is benzo-fused; and wherein Y is one or more a groups selected from hydrido, alkyl, cycloalkyl, halo, haloalkyl, alkenyl, alkynyl, hydroxyl, hydroxy-alkyl, alkoxy, alkoxyalkyl, amino, cyano, nitro and mercapto; or a pharmaceutically acceptable salt thereof.