- Synthesis, molecular structure and multiple biological activities of N-(3-methoxyphenyl)-3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide
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A new molecule of pyridylpyrazole amide (PPA) was successfully synthesized and systematically characterized by using NMR, ESI-MS and absorption (FT-IR and UV–Vis) spectroscopic techniques. The UV–Vis spectral absorption and infrared frequencies were theoretically calculated and compared with observed results. The in vitro biological applications like anti-inflammatory, antioxidant and antidiabetic activities were performed. It exhibited admirable anti-inflammatory activity and antidiabetic, worthy antioxidant activities than standards. The interactions between enzyme-ligand were identified with α-amylase (1HNY.pdb) using the autodock tool. Further Potential energy scan, fukui function and molecular electrostatic potential (MEP) were performed using DFT methods. Finally, In silico pharmacological studies like ADME were implemented for PPA.
- Nithyabalaji, Rajendran,Krishnan, Hariharasubramanian,Sribalan, Rajendran
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- Design, synthesis and antimicrobial evaluation of methyl pyridyl-2,4-dioxobutanoates and Some new derived ring systems
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This work describes the synthesis of new series of compounds derived from methyl pyridyl-2,4-dioxobutanoates that contain pyridine ring attached to substituted bioactive heterocyclic moieties in order to investigate their preliminary in vitro antibacteria
- Elzahhara, Perihan A.S.,Solimana, Raafat,El-Hawash, Soad A.M.,Ragaba, Hanan M.A.,Youssefa, Amal M.,Wahab, Abeer E. Abdel
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p. 407 - 414
(2017/01/06)
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- Design, synthesis and biological screening of some pyridinylpyrazole and pyridinylisoxazole derivatives as potential anti-inflammatory, analgesic, antipyretic and antimicrobial agents
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A series of substituted pyridinylpyrazole (or isoxazole) derivatives was synthesized and evaluated for their antiinflammatory (AI) activity using formalin-induced paw edema bioassays. The inhibitory activities of cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) were also determined. The analgesic activity of the same compounds was evaluated using rat-tail withdrawal technique. Their antipyretic activity was also evaluated. The results revealed that compounds 4a,b, 6a, 8a, 14c and 15a exhibited significant AI and analgesic activities. Compounds 5a, 6a and 8a displayed good antipyretic activity. Compounds 14c and 15a showed good COX-2 inhibitory activity and weak inhibition of COX- 1. Additionally, the most active compounds were shown to have a large safety margin (ALD50 >300-400 mg/Kg) and minimal ulcerogenic potentialities when administered orally at a dose of 300 mg/Kg. Docking studies for 14c and 15a with COX-2 showed good binding profile. Antimicrobial evaluation proved that most of the compounds exhibited distinctive activity against the gram negative bacteria, P. aeruginosa and E coli.
- El-Hawash, Soad A.M.,Soliman, Raafat,Youssef, Amal M.,Ragab, Hanan M.A.,Elzahhar, Perihan A.S.,El-Ashmawey, Ibrahim M.,Wahab, Abeer E. Abdel,Shaat, Iman A.
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p. 318 - 338
(2014/05/06)
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- ORGANIC COMPOUNDS
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Compounds of formula (I) in free or salt form, wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating a condition mediated by activation of the adenosine Alb recep
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Page/Page column 24
(2010/10/19)
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