374063-91-9

Basic information

• Product Name: METHYL 2,4-DIOXO-4-PYRIDIN-4-YLBUTANOATE
• Synonyms: METHYL 2,4-DIOXO-4-PYRIDIN-4-YLBUTANOATE;Methyl 2,4-dioxo-4-pyridin-4-ylbtanoate;4-(3,4-Dioxo-4-methoxybutanoyl)pyridine, Methyl 2,4-dioxo-4-(pyridin-4-yl)butyrate
• CAS NO: 374063-91-9
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.18
• Mol File: 374063-91-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 365.2 °C at 760 mmHg
• Flash Point: 174.6 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 1.6E-05mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 2,4-DIOXO-4-PYRIDIN-4-YLBUTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2,4-DIOXO-4-PYRIDIN-4-YLBUTANOATE(374063-91-9)
• EPA Substance Registry System: METHYL 2,4-DIOXO-4-PYRIDIN-4-YLBUTANOATE(374063-91-9)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 374063-91-9(Hazardous Substances Data)

Usage

General Description

Methyl 2,4-dioxo-4-pyridin-4-ylbutanoate is a chemical compound with the molecular formula C9H7NO4. It is a pyridine derivative and an ester. This chemical is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has potential applications in the fields of medicine and agriculture due to its ability to modify or enhance the activity of various compounds. Additionally, it may be used in research and development for the production of new chemical compounds. However, it is important to handle this chemical with caution and follow proper safety protocols to avoid any adverse effects.

InChI:InChI=1/C10H9NO4/c1-15-10(14)9(13)6-8(12)7-2-4-11-5-3-7/h2-5H,6H2,1H3

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 124-41-4 sodium methylate 
• 95-92-1 oxalic acid diethyl ester 
• 553-90-2 Dimethyl oxalate 

Downstream Products

• 144252-14-2 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylic acid 
• 1620993-20-5 5-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl]-1,3,4-oxadiazole-2-thiol 
• 1620992-56-4 N'-benzylidene-1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide 
• 1620992-08-6 2-[4-bromo-1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl]-5-phenyl-1,3,4-oxadiazole 
• 1620992-88-2 N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide 
• 1620992-57-5 2-(1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl)-N-p-tolylhydrazine-carbothioamide 
• 1620992-13-3 N'-(3,4-diphenylthiazol-2(3H)-ylidene)-1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide 
• 1620992-96-2 1-phenyl-N'-(4-phenyl-3-p-tolylthiazol-2(3H)-ylidene)-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide 
• 1620992-09-7 1-phenyl-N'-(3-phenyl-4-p-tolylthiazol-2(3H)-ylidene)-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide 
• 1621253-68-6 N'-(3,4-di-p-tolylthiazol-2(3H)-ylidene)-1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide 
• 1620992-58-6 N-phenyl-5-(1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl)-1,3,4-oxadiazol-2-amine 
• 1620993-54-5 5-(1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl)-N-p-tolyl-1,3,4-oxadiazol-2-amine 
• 1621253-70-0 N-phenyl-5-(1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl)-1,3,4-thiadiazol-2-amine 
• 1620991-94-7 5-(1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl)-N-p-tolyl-1,3,4-thiadiazol-2-amine 

Relevant articles and documents

Synthesis, molecular structure and multiple biological activities of N-(3-methoxyphenyl)-3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide

A new molecule of pyridylpyrazole amide (PPA) was successfully synthesized and systematically characterized by using NMR, ESI-MS and absorption (FT-IR and UV–Vis) spectroscopic techniques. The UV–Vis spectral absorption and infrared frequencies were theoretically calculated and compared with observed results. The in vitro biological applications like anti-inflammatory, antioxidant and antidiabetic activities were performed. It exhibited admirable anti-inflammatory activity and antidiabetic, worthy antioxidant activities than standards. The interactions between enzyme-ligand were identified with α-amylase (1HNY.pdb) using the autodock tool. Further Potential energy scan, fukui function and molecular electrostatic potential (MEP) were performed using DFT methods. Finally, In silico pharmacological studies like ADME were implemented for PPA.

Design, synthesis and biological screening of some pyridinylpyrazole and pyridinylisoxazole derivatives as potential anti-inflammatory, analgesic, antipyretic and antimicrobial agents

A series of substituted pyridinylpyrazole (or isoxazole) derivatives was synthesized and evaluated for their antiinflammatory (AI) activity using formalin-induced paw edema bioassays. The inhibitory activities of cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) were also determined. The analgesic activity of the same compounds was evaluated using rat-tail withdrawal technique. Their antipyretic activity was also evaluated. The results revealed that compounds 4a,b, 6a, 8a, 14c and 15a exhibited significant AI and analgesic activities. Compounds 5a, 6a and 8a displayed good antipyretic activity. Compounds 14c and 15a showed good COX-2 inhibitory activity and weak inhibition of COX- 1. Additionally, the most active compounds were shown to have a large safety margin (ALD50 >300-400 mg/Kg) and minimal ulcerogenic potentialities when administered orally at a dose of 300 mg/Kg. Docking studies for 14c and 15a with COX-2 showed good binding profile. Antimicrobial evaluation proved that most of the compounds exhibited distinctive activity against the gram negative bacteria, P. aeruginosa and E coli.